Dantrolen (Dantrolene Sodium)

  • Brand Name: Dantrium
  • Innovator Brand Name: Dantrium
  • API: Dantrolene Sodium
  • Dosage Form: 1 Vial
  • Strength: 20mg (60mL)
  • Manufacturer Name: Par Pharmaceutical
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Description

Dantrolene Sodium Uses

Dantrolene is a skeletal muscle relaxant drug used for:

  • Treatment of malignant hyperthermia in conjunction with appropriate supportive measures.
  • Prevention of malignant hyperthermia in patients at high risk.

Dosage: Administer the recommended dosage of dantrolene for treatment of Malignant Hyperthermia by intravenous push at a low or minimum dose of 1 mg/kg. If the physiologic and metabolic abnormalities of MH continue, administer additional intravenous boluses up to the maximum cumulative dosage of 10 mg per kg. In case the physiologic and metabolic abnormalities reappear, repeat dantrolene dosing by intravenous push starting with 1 mg per kg. The recommended prophylactic dosage of dantrolene for prevention of Malignant Hyperthermia is 2.5 mg per kg administered intravenously over a period of at least 1 minute, starting approximately 75 minutes prior to surgery. Avoid agents that trigger MH. If surgery is prolonged, administer additional individualized dantrolene doses during surgery and anesthesia.

Side Effects: The most commonly reported dantrolene side effects include:

  • Weakness in the legs
  • Drowsiness and dizziness
  • Nausea
  • Thrombophlebitis
  • Tissue necrosis secondary to extravasation, urticaria and erythema
  • Injection site reactions (pain, erythema, swelling)

Warnings and Precautions:

  • Patients with dantrolene 20 mg inj should not be permitted to ambulate without assistance until they have normal strength and balance.
  • Dantrolene has been associated with dyspnea, respiratory muscle weakness, and decreased inspiratory capacity. Monitor patients for the adequacy of ventilation.
  • The dantrolene sodium use has been associated with dysphasia. Evaluate patients for difficulty swallowing and choking.
  • Somnolence and dizziness can occur following dantrolene uses. Patients must avoid operating an automobile or engaging in other hazardous activities for 48-hours post-dose.
  • Care must be imposed in order to prevent extravasation of dantrolene into the surrounding tissues due to the high pH of the reconstituted dantrolene suspension and potential for tissue necrosis.
  • The dantrolene sodium should be used during pregnancy only in case the potential benefit justifies the potential risk to the fetus.

More info

Storage: Store unreconstituted product at 20 °C to 25 °C (68 °F to 77 °F), with excursions permitted to 15 °C to 30 °C (59 °F to 86 °F) and avoid prolonged exposure to light. Availability in India: The Indian Pharma helps connect buyers with suppliers who can ship the DANTROLENE at the global level as per the needs of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the DANTROLENE Injections. Buying Procedure: In order to buy DANTROLENE, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +919310090915 or an Email to us at: info@theindianpharma.com along with the legitimate ID Proof, standard Prescription and Medical Reports. Conclusions: Dantrolene is the only currently accepted specific treatment for malignant hyperthermia. Dantrolene is the agent of choice for treating malignant hyperthermia. It greatly reduces the mortality to under 10% if given along with general supportive measures.

FAQ

What is Dantrium IV? Dantrium IV is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in the muscle cells. What does Dantrium contain as an active substance? The medication Dantrium specifically contains the active substance Dantrolene Sodium. What class of drug is Dantrolene? Dantrolene is a class of drugs named Skeletal Muscle Relaxants. How much does dantrium cost? The dantrium price in India usually can vary depending on the wholesaler/pharmacy you visit. Dantrium is available as a brand name drug only, a generic version is not yet available. What is the best price for Dantrolene? Please contact Toll-free: +91 1800 889 1064|+919310090915 for dantrolene price in India. We take the guarantee of quality and delivery anywhere in the world as per the buyer’s requirements. Can I get Dantrium (Dantrolene Sodium) even if I am not based in India? The Indian Pharma helps patients in accessing or importing Dantrium (Dantrolene Sodium), not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country.
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