LONSURF (Trifluridine/tipiracil)

  • Name: LONSURF
  • Generic Name: Trifluridine plus Tipiracil
  • Strength: 15 mg trifluridine/6.14 mg tipiracil and 20 mg trifluridine/8.19 mg tipiracil
    Packing: 60 tablets in one bottle
  • Company: Taiho Pharmaceutical Co. Ltd.
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Description

LONSURF USES

LONSURF is specifically a combination drug of trifluridine, a nucleoside metabolic inhibitor, and tipiracil, a thymidine phosphorylase inhibitor, used to treat adult patients with: metastatic colorectal cancer who have been previously treated with medicine fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with minimum two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if apt, HER2/neu-targeted therapy.

Dosage: The recommended dosage of lonsurf is 35 mg/m2 up to a maximum of 80 mg per dose (based on the trifluridine component) orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle until the disease is progressive or unacceptable toxicity occurs. Round dose to the nearest 5 mg increment. Instruct patients to swallow lonsurf tablets whole. Instruct patients not to retake doses of lonsurf that are vomited or missed and to continue with the next scheduled dose.

Side Effects: The most commonly reported trifluridine side effects include:

  • Anemia
  • Neutropenia
  • Fatigue/asthenia
  • Nausea
  • Diarrhea
  • Vomiting
  • Pyrexia
  • Thrombocytopenia
  • Decreased appetite

Warnings and Precautions:

  • Obtain complete blood counts prior to and on Day 15’th of each cycle of lonsurf 20mg and more frequently as clinically indicated.
  • Monitor patients with lonsurf for complete blood cell counts before and on Day 15 of each cycle. For potential genotoxicity, males with female partners of reproductive potential are advised to use condoms while on treatment with this drug and for at least 90 days after the last dose.
  • Do not initiate treatment with lonsurf chemotherapy in patients with baseline moderate or severe hepatic impairment.
  • Women are advised not to breastfeed while on the treatment with this medication and for one day following the final dose.

More Info.

Storage: Store the Lonsurf Tablets at room temperature between 68°F and 77°F (20°C and 25°C). If you store the tablets outside of the original bottle, throw away (dispose of) any unused tablets after 30 days.

Availability in India: The Indian Pharma helps connect buyers with suppliers who can ship the LONSURF at the global level as per the needs of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the LONSURF Tablets.

Buying Procedure: In order to buy LONSURF, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp +919650877511 or an Email to us at: info@theindianpharma.com along with the legitimate ID Proof, standard Prescription and Medical Reports.

Conclusion: Trifluridine plus tipiracil oral therapy significantly enhanced overall survival and progression-free survival compared with best supportive care alone in the salvage metastatic colorectal cancer and gastric or gastroesophageal junction adenocarcinoma setting.

FAQ

What is LONSURF?
Lonsurf (Trifluridine/Tipiracil) is a fixed-dose combination medicine aimed to treat patients with metastatic colorectal cancer or gastric cancer, after chemo and targeted therapeutics have failed.

How is LONSURF supplied?
LONSURF is supplied as tablets of 15 mg trifluridine/6.14 mg tipiracil and 20 mg trifluridine/8.19 mg tipiracil for oral administration.

In how many countries LONSURF (TAS – 102) is approved for marketing?
LONSURF is available/approved in the USA and Europe. We can help you to access it in India.

How can I get LONSURF (TAS – 102) in India?
LONSURF is a prescription only drug and is not approved for marketing in India.

The Indian Pharma (IP) is a consulting pharmaceutical company which assists Patients in accessing medicines in India. The Indian Pharma facilitates such access only against valid prescriptions in conformity with all local laws and regulations.

Patients/ Clinicians / Researchers can contact IP at Tollfree – +91 1800 889 1064 or write to at –info@theindianpharma.com

We facilitate by-

  • Helping in documentation to import the medicine for personal use

  • Finding Genuine and reliable source in USA, Europe and Japan

  • Ensuring 100% transparency.


LONSURF can be shipped to Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Jaipur, Lucknow, Cochin and Pune and other cities in India.

The Indian Pharma can facilitate the supply of LONSURF (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement.

The Indian Pharma does not manufacture, supply, re-sell or retail any drugs or medicines. All trademarks and other intellectual property in relation to drugs and medicines supplied to you by suppliers are owned by their respective manufacturers or licensees.

Can I get LONSURF even if I am not based in India?
Almost all countries across the world have provisions for granting access to drugs prior to marketing approval for personal use for patients who have exhausted all other treatment options available in their country.

The Indian Pharma (IP) can help patients in accessing/importing LONSURF, unapproved in their home country against a legitimate prescription and in conformity with all local laws and regulations of their home country.

Send your enquiry to find Lonsurf (Trifluridine/tipiracil) in UAE Iraq, Iran, Saudi Arabia, Jordan, Mexico, Argentina, Brazil, Chile, Colombia, Peru, Venezuela, Romania, Switzerland, Georgia, Turkey, Italy, UK, Ukraine, Azerbaijan, Latvia, Poland, Slovakia, Armenia, Kazakhstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan, Mongolia, Algeria, Mauritius, Uganda, Zimbabwe. Australia and New Zealand. China, Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, Vietnam, Hong Kong.

How do I contact The Indian Pharma?
You can use a different channel to contact The Indian Pharma (TIP).
Tele & Mobile: You can reach us on +91 9650877511 or +91-120-4080562.
Email: We can also address your enquiries if sent directly to info@theindianpharma.com. We will respond within 24 hours along with lonsurf cost & procurement details after receiving your mail. Please mention detailed enquiry, your contact number with ISD code while sending your mail. We will respond within 1 working day after receiving your query form.

Documentation

What information do you need to help patient in assisting documentation for LONSURF import for personal use?


We will require the following documents to help in documentation for Named-Patient import




  • Doctor’s Prescription – We would require prescription from Registered Medical Practitioner Stating Product name, dosage, duration of treatment and diagnosis

  • Patient’s Medical history – We would require all test reports and Medical reports of the patient for last 3 months.

  • Patient’s Identity card – We will require scan copy of Patient’s identity card and proof of residence to initiate documentation process. You can use copy of Passport, Driving License, Employee ID card or any Photo ID document as your Identity card.