Facts of Rapamune (Sirolimus)

  • Brand Name- Siromus
  • Innovator Brand Name- Rapamune
  • API- Sirolimus
  • Packaging- 6 Tablets/Strip
  • Strength- 1 mg
  • Manufacturer Name- Zydus
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What is Sirolimus and what it is use for:

Sirolimus is an immunosuppressive agent which is used to prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis sirolimus has immunosuppressant functions and is especially effective in order to prevent the rejection of the kidney transplants.

Dosage: Rapamune should be administered orally once daily, consistently either with or without the food. Avoid the consumption of such tablets which are crushed, chewed or splits. Patients who are not able to consume the tablets should be prescribed for the solution. Initial dose of the sirolimus tablets should be administered immediately after the transplantation. It is recommended that this drug should be taken 4 hours after the administration of the cyclosporine oral solution or cyclosporine capsules.

Treatment Reactions: The most commonly reported sirolimus side effects are as follows:

  • peripheral edema
  • hypertriglyceridemia
  • hypertension
  • hypercholesterolemia
  • creatinine increased
  • constipation
  • abdominal pain
  • diarrhea
  • headache
  • fever
  • urinary tract infection
  • anemia
  • nausea
  • arthralgia
  • pain
  • thrombocytopenia

Warning & Precautions

  • Any patient who is administered Rapamycin must be monitored for hyperlipidemia.
  • Renal function should be precisely monitored during the co-administration of the sirolimus with the cyclosporine.
  • Care should always be exercised when administering agents such as aminoglycosides and amphotericin B that are known to have a deleterious effect on the renal function.
  • During treatment with sirolimus 1 mg, use of live vaccines should be avoided.
  • The use of the siromus 1 mg should be avoided during pregnancy.
  • General supportive measures must be followed in all the cases of drug overdose.
  • In missed dose circumstances, immediately report to your healthcare provider in order to get appropriate medical help.

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How Supplied/Storage and Handling:

Rapamune Tablets always should be stored at 20° to 25°C (68° to 77°F). Cartons should be used in order to protect blister cards and strips from the light. Should dispense in a properly tight and light resistant container.

Alternate Brands of Sirolimus: The alternate brands of sirolimus are as follows:

  • Rapacan 1mg Tablet (Biocon Ltd)
  • Rapasim 1mg Tablet (Alniche Life Sciences Pvt Ltd)
  • Raparen Tablet (La Renon Healthcare Pvt Ltd)
  • Raparen Injection (La Renon Healthcare Pvt Ltd)
  • Sirova 1mg Tablet (Intas Pharmaceuticals Ltd)

Send your inquiry to find Rapamune (Sirolimus) in UAE Iraq, Iran, Saudi Arabia, Jordan, Mexico, Argentina, Brazil, Chile, Colombia, Peru, Venezuela, Romania, Switzerland, Georgia, Turkey, Italy, UK, Ukraine, Azerbaijan, Latvia, Poland, Slovakia, Armenia, Kazakhstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan, Mongolia, Algeria, Mauritius, Uganda, Zimbabwe. Australia and New Zealand. China, Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, Vietnam, Hong Kong.

Kidney Transplant Medications List

  • Prednisone.
  • Tacrolimus (Prograf)
  • Cyclosporine (Neoral)
  • Mycophenolate Mofetil (CellCept)
  • Imuran (Azathioprine)

Conclusion: Sirolimus is a new medication with the immunosuppressant as well as antiproliferative properties that has mainly a unique mechanism of action.