Sebelipase Alfa

Facts of Medicine

  • Brand Name: Kanuma
  • Innovator Brand Name: Kanuma
  • API: Sebelipase Alfa
  • Packaging: 10 ml Vial (Per Box)
  • Strength: 20mg/10ml
  • Manufacturer Name: Alexion Pharma, Inc.
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Uses of medication: Sebelipase alfa is indicated in order to treat patients with a rare disease known as Lysosomal Acid Lipase (LAL) deficiency.

Dosage: Sebelipase alfa is given to you or your child by an infusion (drip) into a vein. The drug will be diluted prior to being given to you or your child. Each infusion will generally take approximately 1-2 hours. You or your child may be monitored by your healthcare practitioner for an additional hour following the infusion. For infants patients (< 6 months of age), the recommended starting dose is 1 mg/kg once weekly. For children and adults, the recommended dose is 1 mg per kg body weight once every other week.

Treatment Reactions: The most commonly reported sebelipase alfa side effects may include:

  • Diarrhea
  • Vomiting
  • Fever
  • Rhinitis
  • Anemia
  • Cough
  • Nasopharyngitis
  • Urticaria
  • Headache
  • Oropharyngeal
  • Pain
  • Asthenia
  • Constipation
  • Nausea

Warnings and Precautions:

  • While on sebelipase alfa 10 ml vial, if you/your child have severe infusion reactions, seek immediate medical assistance.
  • In cases of severe infusion reactions and in cases of lack or loss of effect, patients need to be tested for the existence of antibodies.
  • Sebelipase may be responsible for having a minor influence on the ability to drive as well as use machines. Dizziness has been reported with the use of sebelipase alfa 20 mg which could affect the ability to drive/use machines.
  • In case you’re pregnant or breast-feeding, think you may be pregnant or are planning to conceive a baby, ask your healthcare provider for advice prior to taking this drug.
  • Development of blood proteins against kanuma 20 mg, also named anti-drug antibodies, may occur while on treatment. Talk to your healthcare practitioner in case you have reduced efficacy with this drug.
  • This medication may contain egg proteins. In case you/your child has an egg allergy or a history of allergies to eggs, inform your healthcare provider.

More Info.

Storage: Sebelipase Alfa should be stored under the refrigeration between 2°C-8°C (36°F-46°F) in the original cartons in order to protect from light. Shaking or freezing the vials is not recommended.

Availability in India: The Indian Pharma (TIP) helps connect buyers with suppliers who can ship KANUMA at the global level as per the need of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the KANUMA Injection.

Buying Procedure: In order to buy KANUMA, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +918130290915 or an Email to us at: along with your ID Proof, Valid Prescription Letter and Medical Reports.

Conclusion: The long-term sebelipase alfa dosing in the lysosomal acid lipase-deficient patients is quite well tolerated and produces sus-tained reductions in the transaminases, improvements in the serum lipid profile as well as reduction in the hepatic fat fraction.

Commonly Asked Questions

What does Kanuma 20 mg contain as an active substance?

The kanuma 20 mg specifically contains the active substance sebelipase alfa.

From which class of drug Sebelipase Alfa belongs?

Sebelipase Alfa specifically belongs to a group of medications named human lysosomal acid lipase (rhLAL) proteins.

How does Sebelipase Alfa work?

The sebelipase alfa 20 mg basically is an enzyme replacement therapy, which means that it replaces the missing/defective LAL enzyme in patients with the LAL deficiency. This drug works in order to lower the build-up of fat that basically causes medical complications, including liver damage, impaired growth, and heart complications. It is also involved in improving blood levels of fats, including elevated LDL and triglycerides.

How much does sebelipase alfa cost?

The price of sebelipase alfa injection may vary depending on the pharmacy you visit. The cost for intravenous solution (2 mg/mL) is around 768,168 INar for a supply of 10 milliliters.

Where can I get kanuma at the best price?

In order to get the best kanuma price, always go with a kind of Pharmaceutical Wholesaler Company that holds the ISO certification as well as certification of WHO-GDP.