Irinotecan

Facts of IRINOTECAN

  • Brand Name: Irnocel
  • API: Irinotecan
  • Packaging: Single-use vial
  • Strength: 100 mg/5 mL
  • Manufacturer Name: Celon Labs Ltd
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Description

Irinotecan 100 mg/5 mL injection, supplied generically under the brand Irnocel is an antineoplastic agent used primarily in the treatment of advanced colorectal (colon and rectum) cancer. It is specifically used for patients who have not responded adequately to fluorouracil-based chemotherapy. Irinotecan works by inhibiting the enzyme topoisomerase I, which is essential for DNA replication and repair. This inhibition leads to DNA damage in cancer cells, ultimately causing cell death and reducing tumor growth.

The medicine can be used as a part of combination chemotherapy regimens, often in conjunction with other agents such as fluorouracil (5-FU) and leucovorin (folinic acid). This combination has been shown to enhance the overall efficacy of treatment, leading to better outcomes for patients with metastatic colorectal cancer.

In addition to colorectal cancer, Irinotecan is also being explored for its potential use in treating other types of solid tumors, including small-cell lung cancer, gastric cancer, and pancreatic cancer, although these applications are still under clinical investigation.

The administration of this medicine should be done under the supervision of an experienced oncologist, with careful monitoring for potential side effects, such as severe diarrhea, neutropenia, and gastrointestinal toxicity. Pre-medication with antiemetics is often recommended to manage nausea and vomiting associated with the treatment. Regular blood tests and clinical assessments are essential to ensure patient safety and optimal therapeutic outcomes.

Dosage and Side Effects

The recommended dosage of Irinotecan depends on the treatment regimen and patient factors. For colorectal cancer, a common dosage is 125 mg/m² administered as an intravenous infusion over 90 minutes, once weekly for four weeks, followed by a two-week rest period. Alternatively, a bi-weekly regimen involves 180 mg/m² infused over 90 minutes. Dosage adjustments may be necessary based on patient tolerance, liver function, and hematologic status. Always consult with a healthcare provider for individualized dosing recommendations and to monitor for side effects and efficacy.

The most common side effects of Irinotecan 100 mg/5 mL injection are nausea, weakness, vomiting, diarrhea, loss of appetite, hair loss, and fatigue.

Warning and Precautions

  • Irinotecan injection can cause severe diarrhea, which may lead to dehydration and electrolyte imbalances. Patients should inform their healthcare provider immediately if they experience diarrhea to receive prompt management.
  • Treatment with this drug can suppress bone marrow function, resulting in decreased production of blood cells. Regular blood tests are necessary to monitor blood cell counts, and patients should report any signs of infection or unusual bleeding.
  • Irinotecan-induced neutropenia (low white blood cell count) increases the risk of developing fever due to infection. Patients should seek immediate medical attention if they experience fever, as it may indicate a potentially life-threatening condition.
  • Patients with pre-existing liver disease may be at higher risk of experiencing severe adverse effects from Irnocel 100 mg/5 mL injection. Liver function tests should be monitored regularly, and dosage adjustments may be necessary.
  • Irinotecan metabolism is affected by drugs that inhibit the CYP3A4 enzyme. Concurrent use of such medications can increase Irinotecan levels in the body, leading to toxicity. Healthcare providers should be informed of all medications being taken to avoid harmful interactions.
  • This therapeutic drug can cause fetal harm if administered during pregnancy and should be avoided. It is also not recommended during breastfeeding due to the potential for adverse effects on the infant.

FAQ's

What is the active substance in Irnocel?

Irinotecan is the active substance in Irnocel.

How is Irinotecan supplied?

Irinotecan is supplied in the form of Injection: 100 mg/5 mL in a single-dose vial for intravenous (IV) use.

How much does Irinotecan cost?

Please Call/WhatsApp: +91 8130290915 or dial our TOLL-FREE: 1800-889-1064 to get the exact cost of Irinotecan 100 mg/5 mL injection. If you want to buy Irinotecan online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price through legal channels.

Is Irinotecan Available In India?

Irinotecan is a pharmaceutical prescription medicinal product that can be only dispensed against a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of Irinotecan to all locations after fulfilling the legal requirement (if applicable). Please contact us via +91 8130290915 | TOLL-FREE: 1800-889-1064 or write us at info@theindianpharma.com to buy generic Irinotecan from India at the best price.

Can I get Irinotecan even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access Irinotecan, not approved in their home country against the valid prescription and in conformity with the local laws and regulations of their respective country.

Where can I get Irinotecan at the best price?

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Is it safe to buy generic Irinotecan online from India?

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