Uses of medication: Lesinurad is prescribed together with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with gout in such patients who haven’t got target serum uric acid levels with a xanthine oxidase inhibitor alone.
Dosage: Lesinurad tablets are for oral use and prescribed to be co-administered with the xanthine oxidase inhibitor, including allopurinol or febuxostat. Lesinurad is recommended at 200 mg once daily. The lesinurad dosage should be taken by mouth at about the same time in the morning with food and water.
Treatment Reactions: Most commonly reported side effects due to lesinurad for gout may include:
- Blood creatinine increased
- Gastroesophageal reflux disease
Warnings and Precautions:
- In case treatment with the xanthine oxidase inhibitor is interrupted, zurampic 200 mg should also be interrupted.
- So not use this medication as a monotherapy.
- Patients must be instructed to stay well hydrated (eg, 2 liters/68 oz of liquid daily).
- The lesinurad uses are not recommended in case you’re a woman of childbearing potential or you’re breastfeeding.
- Renal function assessment is recommended before initiation of therapy and periodically thereafter.
- Use of lesinurad is not recommended in order to treat asymptomatic hyperuricemia.
- In case a gout flare occurs while on lesinurad treatment, lesinurad need not be interrupted. The gout flare can be managed concurrently.