GLEEVEC (Imatinib Mesylate)

Facts of GLEEVEC
  • Brand Name: GLEEVEC
  • Medicine Name: Imatinib Mesylate
  • Company Name: Natco Pharma
  • Supplied as: 100mg & 400mg.10 tablets in one strip.
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Description

What is GLEEVEC ™?

GLEEVEC is indicated for the treatment of

  • Newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase. Follow-up is limited to 5 years
  • Patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in blast crisis (BC), accelerated phase (AP), or in chronic phase (CP) after failure of interferon-alpha therapy
  • Pediatric patients with Ph+ CML in chronic phase who are newly diagnosed or whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy.
  • Adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL)
  • Adult patients with myelodysplastic/ myeloproliferative diseases (MDS/MPD) associated with PDGFR (platelet-derived growth factor receptor) gene re-arrangements
  • Adult patients with aggressive systemic mastocytosis (ASM) without the D816V c-Kit mutation or with cKit mutational status unknown
  • Adult patients with hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1-PDGFRα fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-PDGFRα fusion kinase negative or unknown
  • Adult patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans (DFSP)
  • Patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).

Gleevec (imatinib mesylate) uses: Imatinib mesylate belongs to kinase inhibitor class drug used in the treatment of several diseases such as:

  • Imatinib mesylate is effective in the treatment of gastrointestinal stromal tumor with C-Kit positive. It is one of the best medications for gastrointestinal stromal tumor treatment. A patient diagnosed with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in their chronic phase.
  • The patient has undergone interferon-alpha therapy or stem cell transplant suffering from chronic myeloid leukemia.
  • This therapy is effectively used in the treatment of myelodysplastic/ myeloproliferative diseases (MDS/MPD).
  • Patients surviving with aggressive systemic mastocytosis (ASM) or chronic eosinophilic leukemia (CEL) are taking this drug.
  • Metastatic dermatofibrosarcoma protuberans (DFSP) in patients are treated with this therapy.

General warning: Edema and severe fluid retention are common in a patient taking this medication. This drug when taken in case of pregnancy may cause potential harm to the embryo.

Additional Information

How does Gleevec work?


Gleevec belongs to targeted therapy class drugs. This therapy works by detecting the internal structure and functioning of the cell. This drug blocks or inhibits the major cell cycle of growth division.
Imatinib mesylate belongs to the signal transduction inhibitor subclass of kinase inhibitor class drug. These work by inhibiting the protein tyrosine activity by interrupting the signal.


Gleevec (imatinib mesylate) side effects: The most frequently reported side effect of this drug is mentioned below:


  • Abdominal pain

  • Nausea

  • Muscle cramp

  • Constipation

  • Edema

  • Indigestion

  • Vomiting

  • Rash

  • Shortness of breath

  • Diarrhea

  • Fatigue

  • musculoskeletal pain

  • Joint pain

  • Cough

  • Weakness

Gleevec (imatinib mesylate) cost: Gleevec (imatinib mesylate) FDA label is inexpensive and cost-friendly. It exists at all the registered and legitimate pharmaceutical companies. This drug can also be ordered online by placing an order on the Pharmaceutical official website.


Dosage: This drug is available in a tablet form of two different concentrations 100mg and 400mg. It is consumed orally once or twice daily according to the doctor’s prescription. This pill is taken after a meal along with a glass of water.
The dosage of tablets depends upon several factors such as health problems, stage of cancer, type of cancer, and general health of the patient.


Precautions:


  • Before taking this drug to discuss with your health care professional about any allergy with an active or inactive ingredient of the tablet.

  • Some pain remedies such as Acetaminophen should not be taken.

  • Do not take any vaccination or immunization during this therapy.

  • Take an appropriate contraceptive method to avoid any chances of pregnancy.

  • If this drug is necessary for pregnant women, the dosage should be adjusted accordingly so that it does not cause any potential damage.

  • Breastfeeding is strictly prohibited while taking this medication.

Interaction: When other medications are taken along with imatinib mesylate they may all have a different effect on the specific tablet. Such drug interactions are listed below:


  • CYP3A4 inducers, when taken along with imatinib, may decrease its concentration.

  • CYP3A4 inhibitors increase the concentration of Gleevec.

  • Imatinib is an inhibitor of CYP3A4 that increases the concentration of Other Drugs.

Overdose: In case of overdose, patients should not take any medication according to itself as it may cause fatalities. The patient should consult a doctor if trouble breathing occurs due to dose uptaking.


Missed dose: If any dose is accidentally missed take the missed dose as soon as you remember.
Do not take two doses at a time as it may cause an overdose condition.

Commonly Asked Questions

What are the self-care tips while taking Glivec?


  • This medication should be taken after a meal along with a large glass of water to reduce constipation or stomach upset.

  • Avoid going to crowded places as it may increase the risk of infection reporting cold and fever.

  • Drink at least two to three liters of water in the 24-hour cycle.

  • Avoid any sports or activities that may cause injury.

  • Consumption of alcoholic beverages should be minimum.

  • Take at least 7-8 hours of sleep in 24 hours.

  • Eat nutritious food.

  • Avoid any instrument or machine that may result in cut or bleeding.

What is the best price of GLEEVEC?


Please contact 1800 889 1064 for GLEEVEC price in India
We take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.


Where can I Buy GLEEVEC?


The Indian Pharma connects buyer with the supplier who can ship GLEEVEC to any country of the world as per the buyer’s requirement and Government regulations of the country. GLEEVEC is manufactured by Natco Pharma.
The Indian Pharma provides options of choosing exporter and supplier of cancer treatment medicines. We take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.

Availability

GLEEVEC is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.


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