Orfadin (Nitisinone)

About Medicine

  • Name: ORFADIN
  • Generic Name: Nitisinone
  • Strength: 2 mg, 5 mg, 10 mg
  • Company: Swedish Orphan Biovitrum International AB
  • Packing: Each bottle contains 60 capsules
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Description

General Warning: This medication should not be used during pregnancy unless the clinical condition of the woman needs treatment with the nitisinone. Also, mothers taking this drug must avoid breast-feeding.

Orfadin – Nitisinone 2 mg, 5 mg, 10 mg is supplied for Tenders, Emergency imports, Orphan drug, Reference listed drugs, Comparator Drug, Name patient medicine and Innovator samples etc.

What is ORFADIN:

ORFADIN is a medicine that contains the active substance Nitisinone and is available as Capsules.

How Does Nitisinone(Orfadin) Work?

Nitisinone helps stop the build-up of the toxic substances which can be responsible for causing the severe liver and also kidney problems in patients with the HT-1. In order to do that, it is also helpful in preventing the porphyric crises associated with the HT-1.

In how many countries ORFADIN is approved for marketing?

ORFADIN is available/approved in USA and Europe. We can help you to access it in India.

What is ORFADIN used for?

It is used for the treatment of hereditary tyrosinemia type 1 (HT-1), in addition to limiting the amount of tyrosine and phenylalanine in the diet.

Nitisinone side effects: Patients with this drug may experience some most common side effects which are eye pain, elevated tyrosine levels, conjunctivitis, corneal opacity, keratitis, photophobia, leukopenia, blepharitis, granulocytopenia, epistaxis, exfoliative dermatitis, dry skin, alopecia, cataracts, pruritus, thrombocytopenia and maculopapular rash.

Nitisinone cost: Nitisinone 2 mg, 5 mg, 10 mg is available at a very promising rate.

Nitisinone FDA label should be taken twice a day. Nitisinone should be taken with or without meal however, it should always be taken at about the same way. Therefore, if you start taking this drug with food, you should always take it with food.

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Precautions:

  • Treatment with this drug (Nitisinone) must be initiated and supervised by the physician who is experienced for treating HT-1.
  • Your healthcare professional will tell you how much Nitisinone to take and when to take it.
  • Your healthcare professional will check your eyes prior to initiating treatment with Nitisinone.
  • For children, Nitisinone capsules can be opened and the contents sprinkled into a little bit of water or formula immediately prior to use.
  • This medication must be avoided while breastfeeding.
  • Avoid the consumption of this drug if you think you are allergic to it.
  • Nitisinone can cause abnormal blood test results. While you are taking this medication your healthcare provider will determine when to perform blood tests.
  • Opened bottles of nitisinone 2 mg capsules should be stored for 30 days at the room temperature (not more than 25°C); then discarded.
  • Opened bottles of Nitisinone 5 mg, 10 mg and 20 mg capsules should be stored for 3 months at room temperature (not more than 25°C); then discarded.

Interactions: The use of nitisinone with medications that are metabolized by the CYP2C9, additional and watchful monitoring can be warranted because of the potential for the increased systemic exposure of these medications. The risk is dependent upon the particular 2C9 substrate and the profile of its adverse reaction.

Overdose: In an event of taking too much drug (nitisinone), immediately call your doctor, or contact the regional Poison Control Centre or nearest hospital emergency department, even if there are no signs and symptoms.

Missed Dose: If you miss a dose by less than 12 hours, take it as soon as you remember.

Availability

How can I get ORFADIN in India? ORFADIN is a prescription-only drug and is not approved for marketing in India. The Indian Pharma (IP) is a consulting pharmaceutical company which assists Patients in accessing medicines in India. The Indian Pharma facilitates such access only against valid prescriptions in conformity with all local laws and regulations. Patients/ Clinicians / Researchers can contact IP at Tollfree – +91 1800 889 1064 or write to at –info@theindianpharma.com We facilitate by –
  • Helping in documentation to import the medicine for personal use
  • Finding Genuine and reliable source in USA, Europe and Japan
  • Ensuring 100% transparency.
ORFADIN can be shipped to Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Jaipur, Lucknow, Cochin and Pune and other cities in India. The Indian Pharma can facilitate the supply of ORFADIN (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement. The Indian Pharma does not manufacture, supply, re-sell or retail any drugs or medicines. All trademarks and other intellectual property in relation to drugs and medicines supplied to you by suppliers are owned by their respective manufacturers or licensees Can I get ORFADIN even if I am not based in India? Almost all countries across the world have provisions for granting access to drugs prior to marketing approval for personal use for patients who have exhausted all other treatment options available in their country The Indian Pharma (IP) can help patients in accessing/importing ORFADIN, unapproved in their home country against a legitimate prescription and in conformity with all local laws and regulations of their home country. Send your enquiry to find ORFADIN (Nitisinone) in UAE Iraq, Iran, Saudi Arabia, Jordan, Mexico, Argentina, Brazil, Chile, Colombia, Peru, Venezuela, Romania, Switzerland, Georgia, Turkey, Italy, UK, Ukraine, Azerbaijan, Latvia, Poland, Slovakia, Armenia, Kazakhstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan, Mongolia, Algeria, Mauritius, Uganda, Zimbabwe. Australia and New Zealand. China, Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, Vietnam, Hong Kong. How do I contact The Indian Pharma? You can use different channel to contact The Indian Pharma (IP) Tele & Mobile: You can reach us on +91 8826990915 or +91 1800 889 1064 on any working days. Email: We can also address your enquiries if sent directly to info@theindianpharma.com. We will respond within 24 hours after receiving your mail. Please mention detailed enquiry, your contact number with ISD code while sending your mail. We will respond within 1 working days after receiving your query form. What information do you need to help patient in assisting documentation for ORFADIN import for personal use? We will require the following documents to help in documentation for Named-Patient import
  • Doctor’s Prescription – We would require prescription from Registered Medical Practitioner Stating Product name, dosage, duration of treatment and diagnosis
  • Patient’s Medical history – We would require all test reports and Medical reports of the patient for last 3 months.
  • Patient’s Identity card – We will require scan copy of Patient’s identity card and proof of residence to initiate documentation process. You can use copy of Passport, Driving License, Employee ID card or any Photo ID document as your Identity card.

Relevant

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Numbers of people out there have never even heard about VWD, the world’s most common inherited bleeding disorder. It is named after the Finnish physician who discovered or identified it in the year of 1920, affects approximately 1 out of 100 people across the world, impacting male and female equally.

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