Ivosidenib

Fact of Medicine
Brand Name: Tibsovo
Innovator Brand Name: Tibsovo
API: Ivosidenib
Packaging: 60 Tablets
Strength: 250mg
Manufacturer Name: Agios Pharma, Inc.

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Description

Ivosidenib Medications

Tibsovo (Ivosidenib) is an isocitrate dehydrogenase-1 (IDH1) inhibitor used to treat adults with newly-diagnosed acute myeloid leukemia (AML) who are aged ≥ 75 years old, and adult patients with relapsed or refractory acute myeloid leukemia (AML).

Dosage: The recommended dose of ivosidenib is 500 mg administered orally once daily until the disease is progressive or in occurrence of unacceptable toxicity. Administer the dose of ivosidenib 500 mg with or without food. It is not advised to administer the pills with a high fat meal due to an increase in the ivosidenib concentration. Do not split or crush ivosidenib tablets. Administer the ivosidenib tablets by mouth at around the same time every day. If any dose of ivosidenib is vomited, patients are advised to avoid administering a replacement dose and wait until the upcoming scheduled dose is due. If an ivosidenib dose is missed or not administered at about the usual schedule, administer that dose promptly and at least 12 hours before the next scheduled dose. Return to the normal dosing schedule the following day. Strictly avoid administering 2 doses within 12 hours.

Side Effects: The most commonly reported ivosidenib side effects may include:

  • Fatigue
  • Arthralgia
  • Leukocytosis
  • Diarrhea
  • Edema
  • NauseaDyspnea
  • Mucositis
  • Rash
  • Cough
  • Decreased appetite
  • Myalgia
  • Constipation
  • Pyrexia
  • Electrocardiogram QT prolonged

Warnings and Precautions:

  • Patients with therapy ivosidenib 250 mg should be monitored for electrolytes and electrocardiograms (ECGs). Monitor patients taking ivosidenib 500 mg for onset of new signs/symptoms of motor and sensory neuropathy.
  • The use of tibsovo 500 mg may cause fertility complications in females and males, which may affect their ability to have children.
  • Nursing women are advised not to breastfeed while on ivosidenib dosage and for at least 1 month following the last dose.
  • Use of tibsovo tablets could be responsible for causing harm to fetus. Patients are advised to avoid conceiving a baby while on treatment with it.
  • Blood tests of respective patients should be done prior to initiating and during treatment with tibsovo 250 mg.

More info

Storage: Store Tibsovo (Ivosidenib tablets) at temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F). Availability in India: The Indian Pharma helps connect buyers with suppliers who can ship the TIBSOVO at the global level as per the needs of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the TIBSOVO Tablets. Buying Procedure: In order to buy TIBSOVO, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +919310090915 or an Email to us at: info@theindianpharma.com along with your valid Identity Proof, Legitimate Prescription letter and Medical Reports. Conclusion: Ivosidenib (Tibsovo), a novel oral inhibitor, shown the durable remissions as well as promising tolerability in adult patients with relapsed/refractory AML with mutation known as IDH1. Although certain other different new treatments have been approved by the FDA to treat patients with AML, the FDA approval of ivosidenib tablets demonstrats the first treatment option that is involved in targeting the IDH1 mutation. Approval of ivosidenib offers a new treatment option for patients with relapsed/refractory AML whose disease is associated with the mutation named IDH1.

FAQ

What is Tibsovo? Tibsovo is a prescription agent used to treat adult patients with acute myeloid leukemia (AML). What does Tibsovo contain as an active substance? The medication Tibsovo specifically contains the active substance Ivosidenib. Is Ivosidenib an FDA approved drug? Yes, Ivosidenib is an FDA approved drug. How is Ivosidenib used? Ivosidenib is a tablet. Two tablets (total of 500 mg) are administered once daily. How much does tibsovo cost? The tibsovo 250 mg tablet price usually may vary depending on the wholesaler/pharmacy you visit and of course the brand you choose. What is the best price of Ivosidenib? Please contact Toll-free: +91 1800 889 1064|+919310090915 for ivosidenib price in India. We take guarantee of quality as well as delivery anywhere in the world as per the buyer’s requirements. Can I get Tibsovo (Ivosidenib) even if I am not based in India? The Indian Pharma helps patients in accessing or importing Tibsovo (Ivosidenib), not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country

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