• Generic Brand Name- SHILGEM 200 MG
  • Innovator Brand Name- Gemzar
  • API- Gemcitabine
  • Packaging- Single Vial
  • Strength- 1 G|200 mg
  • Manufacturer Name- Shilpa Medicare
Get Price


What is Gemcitabine and what it is used for:

Gemcitabine belongs to a nucleoside metabolic innovator class drug that is generally used in combination with carboplatin to treat advanced ovarian cancer in a patient who has received at least one prior platinum-based therapy. This drug is also used to treat metastatic breast cancer when combined with paclitaxel and non-small-cell lung cancer in combination with cisplatin, as single-agent Gemcitabine is recommended for treating pancreatic cancer.

Mechanism of Action of Gemcitabine:

Gemcitabine kills cells undergoing DNA synthesis and blocks the progression of cells through the G1/S-phase boundary. Gemcitabine is metabolized by nucleoside kinases to diphosphate (dFdCDP) and triphosphate (dFdCTP) nucleosides. Gemcitabine diphosphate inhibits ribonucleotide reductase, an enzyme responsible for catalyzing the reactions that generate deoxynucleoside triphosphates for DNA synthesis, resulting in reductions deoxynucleotide concentrations, including dCTP. Gemcitabine triphosphate competes with dCTP for incorporation into DNA. The reduction in the intracellular concentration of dCTP by the action of the diphosphate enhances the incorporation of gemcitabine triphosphate into DNA (self-potentiation). After the Gemcitabine nucleotide is incorporated into DNA, only one additional nucleotide is added to the growing DNA strands, eventually initiating apoptotic cell death.

Dosage: This drug is available in injection form of different concentrations used to treat ovarian cancer, breast cancer, non-small cell lung cancer, and pancreatic cancer.

  • Ovarian Cancer: The recommended dosage of Gemcitabine is 1000 mg/m2 should be given intravenously over the 30 minutes on Days 1 and 8 of each 21-day cycle in combination with carboplatin AUC 4 administered intravenously on Day 1 after the administration of Gemcitabine.
  • Breast Cancer: The recommended dosage of this drug is 1250 mg/m2 intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle in combination with paclitaxel 175 mg/m2 administered as a 3-hour intravenous infusion on Day 1 before the administration of gemcitabine injection.
  • NSCLC: The recommended dose of Gemcitabine is 1000 mg/m2, which should be given intravenously over the 30 minutes on Days 1, 8, and 15 of each one-month cycle together with the cisplatin 100 mg/m2 administered intravenously on Day 1’st after the administration of gemcitabine injection. Pancreatic Cancer: The recommended dose for pancreatic cancer is 1000 mg/m2, recommended intravenously over 30 minutes.

Treatment Reactions: The most common side effects of Gemcitabine are given as follows:

  • Peripheral edema
  • Vomiting
  • Hepatic transaminitis
  • Anemia
  • Fever
  • Increased alkaline phosphatase
  • Dyspnea
  • Thrombocytopenia

Additional Info.

Warning & Precautions

  • The myelosuppression manifested by neutropenia, thrombocytopenia, and anemia occurs with Gemcitabine as a single agent, and the risks are increased when Gemcitabine is combined with other cytotoxic drugs.
  • There are reports of pulmonary toxicity, including interstitial pneumonitis, pulmonary fibrosis, pulmonary edema, and adult respiratory distress syndrome (ARDS) in patients administered Gemcitabine. Discontinue the dosage of Gemcitabine in patients who develop unexplained dyspnea, with or without bronchospasm, or have any evidence of pulmonary toxicity.
  • Hemolytic Uremic Syndrome can occur in patients treated with Gemcitabine. Permanently discontinue the administration of this drug in patients with HUS or severe renal impairment. Renal failure may not be reversible even with the discontinuation of therapy.
  • Gemcitabine can cause fetal harm when administered to a pregnant woman, based on its mechanism of action.

How Supplied/Storage and Handling:

Gemcitabine is stored at room temperature 20° to 25°C (68° to 77°F). The temperature is maintained so that the drugs do not degrade in hospital warehouses or in pharmacies.

Buying Procedure The Indian Pharma connects the buyer with the supplier to supply Gemcitabine to any country per the buyer’s requirement and Government regulations. The Indian Pharma provides options for choosing exporters and suppliers of cancer treatment medicines. We guarantee quality and delivery anywhere in the world as per the buyer’s needs.

Alternate Brands of Gemcitabine: The alternate brands of gemcitabine are as follows:

  • Gemibine 1gm Injection 1’s (Intas Pharmaceuticals Ltd)
  • Stricyte 1000mg Injection 1’s (Mylan Pharmaceuticals Pvt Ltd)
  • Gemitrate 1000mg Injection 1’s (Torrent Pharmaceuticals Ltd)
  • Mygem 1000mg Injection 1’S (Mylan Pharmaceuticals Pvt Ltd)
  • Gemtrust 1000mg Injection 1’S (Panacea Biotec Ltd)
  • Gemcite 1000mg Injection 1’S (Eli Lilly And Company (India) Pvt Ltd)
  • Emcitaben 1000mg Injection 1’S (Rpg Life Sciences Ltd)
  • Gemacta 1000mg Injection 1’S (Macleods Pharmaceuticals Pvt Ltd)
  • Tabicad 1000mg Injection 1’S (Cadila Pharmaceuticals Ltd)
  • Gemchem 1000mg Injection 1’S (Neon Laboratories Ltd)


What are the ingredients in the medicine Gemcitabine 200 mg? The active ingredient in the medicine is Gemcitabine, and the inactive ingredients are mannitol and sodium acetate. How to store the medicine Shilgem? Unopened vials of the medicine are stable until the expiration date indicated on the package when stored at a controlled room temperature of 20° to 25°C (68° to 77°F).

Does Gemcitabine Cause Hair Loss?

Normally Gemcitabine does not cause hair loss; however, patients may experience hair loss in a few cases.

What is the Treatment Cycle of Gemcitabine?

This drug is generally given for approximately four weeks.

Is Gemcitabine a Strong Chemotherapy Drug?

Gemcitabine is a chemotherapy drug used to treat several cancers such as breast cancer, non-small cell lung cancer, ovarian cancer, and pancreatic cancer.

Whom to connect for the best price of Gemcitabine?

For any query related to gemcitabine price in India, you can call us on our Toll-Free- +91 1800 899 1064 or What’s App us on +91 8130290915.