Kryxana (Ribociclib)

Facts of KRYXANA

  • Brand Name: KRYXANA
  • Medicine Name: Ribociclib 200 mg
  • Company Name: Novartis Pharma
  • Supplied as: Pack of 21 tablets
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Description

KRYXANA (Ribociclib 200 mg); is a registered trademark of Novartis Pharma.

General Warning: Regular use of Ribociclib causes disturbance in QT prolongation. This QT prolongation causes cardiovascular problems. Intake of Ribociclib can cause fetal damage.

Uses of Kryxana (Ribociclib) 200 mg Tablet

  • Treatment of perimenopausal or postmenopausal women having breast cancer.
  • This medication is combined with fulvestrant to treat postmenopausal women having breast cancer.

Breast Cancer and its Causes:-

Breast cancer is one of the most common cancers that form in the cell of the breast. Breast cancer can arise both in men and women; however, it is more popular in women. Breast cancer arises when a few cells grow and become abnormal. These abnormal cells divide more rapidly than healthy cells and accumulate to form a lump.

Causes of breast cancer are:
  • Inheritance
  • Increasing age
  • Radiation exposure
  • Obesity
  • Postmenopausal hormonal therapy

This medicine is combined with other medicines to treat hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer.

Signs of Breast Cancer: Few symptoms of breast cancer are mentioned below:

  • The skin over the breast changes.
  • Size and shape of breast change.
  • There is pigmentation around the nipple causing peeling, crusting or flaking of skin.
  • Redness all over the breast
  • Nipple becomes inverted.
  • Lump formation occurs which tightens the breast in comparison to other parts of the body.

Commonly asked questions

How is Breast Cancer Diagnosed?


  • There are some techniques and tests that are used to recognize breast cancer. These are mentioned below:

  • Breast examination: The doctor and the patient too can touch the breast and find out any lump or abnormality.

  • Mammogram: A mammogram is simply the X-ray of the break. It is used to detect any abnormality.

  • Breast ultrasound: Ultrasound is used to produce images. It is used to determine the breast lump or cyst formation.

  • Biopsy: A biopsy is done after diagnosing the size and shape of the cancer. With the help of surgery, the cancerous tumor is removed.

What is the treatment of Breast Cancer?

Ribociclib FDA label is a kinase inhibitor class drug that is used in breast cancer treatment, which mainly occurs in the postmenopausal women having hormone receptor-positive and human epidermal growth factor receptor 2 negatives at advanced or metastatic breast cancer.

What is KRYXANA (Ribociclib) 200 mg?


KRYXANA 200mg is a kinase inhibitor indicated in combination with an aromatase inhibitor as initial endocrine-based therapy for treating postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer.

How Does Ribociclib Works?

Ribociclib is a targeted therapy drug that is used in the treatment of breast cancer. In the case of positive breast cancer, the proteins that help in the division of cancerous cells to form new cells are blocked by Ribociclib. Ribociclib works by preventing the cell from moving from G1 to A cell cycle phase in the cell cycle division. This inhibition results in a slow cancer growth rate.

Ribociclib Side Effects:


Some common side effect of Ribociclib are:


  • Nausea

  • Vomiting

  • Diarrhea

  • Hair loss

  • Low blood count

  • Elevation in liver enzymes

  • Fatigue

Severe adverse reactions of this medication are:


  • QT prolongation

  • Faintness

  • Tiredness

  • Irregular heartbeat

How to Administer Ribociclib


  • Oral Administration

  • Take ribociclib and letrozole at approximately the same time each day, preferably in the morning

  • May take with or without food

  • Swallow tablets whole; do not chew, crush, or split before swallowing

  • No tablet should be ingested if it is broken, cracked, or otherwise not intact

  • Missed or vomited dose: No additional dose should be taken that day; take the next dose at the usual time

How to store Ribociclib?


Store at 20-25°C (68-77°F) in the original package.


What is the cost of Ribociclib?


The Ribociclib price is very economical if you purchase from the Indian market, the reason is the availability of generic brands with same composition. It is available at all pharmaceutical companies that are registered legally. This medication can also be ordered online through the various websites of the company.

Additional Info.

Dosage: The Ribociclib is present in a tablet form of a concentration of 200mg. The recommended starting dose of Ribociclib is 600 mg taken for 21 days with or without food followed by 7 days off treatment.


Precaution


  • QT interval prolongation: Monitoring of electrocardiogram and electrolyte should be done during breast cancer treatment with Ribociclib.

  • Hepatobiliary toxicity: Increase in the level of serum transaminase is being observed.

  • The use of this medication should be avoided in case of pregnancy. During recent research, it has been found to cause fetal damage.

Interaction


  • CYP3A4 Inhibitors: Avoid the use of Ribociclib with strong CYP3A inhibitors.

  • CYP3A4 Inducers: Avoid concomitant use of Ribociclib with strong CYP3A inducers.

  • CYP3A substrates: The dose of sensitive CYP3A substrates with narrow therapeutic indices may need to be reduced when given concurrently with Ribociclib.

Overdose: The overdose of Ribociclib may cause trouble breathing. If trouble breathing occurs then the patient should immediately consult a doctor.

Missed Dose: If any dose of the patient is missed then take the next dose at a regular time. Do not rush to take the missed dose as it can cause overdose.


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