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polivy polatuzumab vedotin-piiq

  • Medicine Name: Polivy
  • API: Polatuzumab Vedotin-piiq
  • Dosage Form: 1 Vial (Per Box)
  • Strength: 30 mg/140 mg
  • Manufacturer Name: Genentech, Inc.
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Description

  • Polivy (polatuzumab Vedotin-piiq) is a CD79b-directed antibody and microtubule inhibitor conjugate used: in combination with a rituximab product, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for the treatment of adult patients who have previously untreated diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) or high-grade B-cell lymphoma (HGBL) and who have an International Prognostic Index score of 2 or greater.
  • in combination with bendamustine and a rituximab product for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), NOS, after at least two prior therapies.

Posology & Administration: Patients with Previously Untreated DLBCL, NOS, or HGBL: The prescribed dose of Polivy injection is 1.8 mg/kg, given via intravenous infusion once every 21 days for a total of 6 cycles. It is combined with a rituximab product, cyclophosphamide, doxorubicin, and prednisone. On Day 1, Polivy, cyclophosphamide, doxorubicin, and the rituximab product are administered in any sequence following the administration of prednisone. Prednisone is given from Day 1 to Day 5 of each cycle.

Patients with Relapsed or Refractory DLBCL, NOS: The prescribed regimen for Polivy entails administering 1.8 mg/kg intravenously every 21 days for six cycles in conjunction with bendamustine and a rituximab product. On Day 1 of each cycle, Polivy, bendamustine, and the rituximab product should be administered in any sequence. Bendamustine should be given at a dose of 90 mg/m2/day on Days 1 and 2 when used with Polivy and a rituximab product. Additionally, the recommended dose of the rituximab product is 375 mg/m2 intravenously on Day 1 of every cycle.

If a scheduled dose is missed, administer it promptly and adjust the dosing schedule to maintain a 21-day interval between doses.

Important Safety Information

Infusion-Related Reactions: Polivy 30 mg/140 mg can cause infusion-related reactions, including fever, chills, nausea, and hypotension. Patients should be monitored closely during and after infusion, and appropriate supportive care should be provided as required.

Hepatotoxicity: Treatment with this medicine may result in hepatotoxicity, characterized by elevated liver enzymes and liver dysfunction. Liver function tests should be performed regularly during treatment, and therapy should be interrupted or discontinued if hepatotoxicity occurs.

Progressive Multifocal Leukoencephalopathy (PML): PML, a rare and serious brain infection caused by the JC virus, has been reported in patients treated with Polatuzumab Vedotin-piiq. Patients should be monitored for symptoms of PML, including changes in mental status, weakness, and vision changes, and treatment should be discontinued if PML is suspected.

Serious Infections: Polatuzumab Vedotin may increase the risk of serious infections, including bacterial, fungal, and viral infections. Patients should be monitored for signs and symptoms of infection, and appropriate antimicrobial therapy should be initiated as needed.

Tumor Lysis Syndrome (TLS): TLS, characterized by metabolic abnormalities such as hyperuricemia, hyperkalemia, hypocalcemia, and hyperphosphatemia, can occur with Polivy treatment. Patients with high tumor burden or rapidly proliferating tumors are at increased risk. Hydration and close monitoring of electrolytes are recommended to prevent TLS.

Infertility: This therapeutic drug may be responsible for causing infertility in both males and females. Patients should be counseled on the potential risks of infertility and may consider fertility preservation options before starting treatment.

Documentation & Availability

What documents are required to import POLIVY to India? POLIVY (Polatuzumab Vedotin-piiq) injections can be imported by patients or government hospitals on the name of the patients only. The following documentation is needed to import the product:
  • A valid prescription from a qualified doctor.
  • Patients diagnostic reports
  • Patient ID proof (issued by the government of India)
How does the order be confirmed? The order will be confirmed only after the receipt of:
  • Valid prescription of Doctor
  • Import permit if applicable
Is POLIVY available in India? POLIVY (Polatuzumab Vedotin injection) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed. IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input On availability of Polivy in India (Kolkata, Hyderabad, Mumbai, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.) Medicine Price. Finding Authentic and reliable sources from USA, Canada, Europe, and Australia Ensuring 100% transparency. POLIVY can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit. TIP (The Indian Pharma) can facilitate the supply of POLIVY (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable). Please contact +91-9310090915 | Toll-Free No: 1800-889-1064 or write us at info@theindianpharma.com for the price of Polivy in India. We guarantee quality and delivery in every corner of the world as per the buyer’s requirements.

Sourcing & Delivery

The Indian Pharma (TIP) can source POLIVY (Cancer Treatment Medicines) from across the globe and can supply. TIP offers its customers worldwide access to the best available treatment.

The Indian Pharma (TIP) has the potential to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.

FAQS

What does Polivy contain as an active substance?

Polivy contains the active substance Polatuzumab Vedotin-piiq.

How is Polivy supplied?

Polivy is supplied for injection: 30 mg or 140 mg of polatuzumab vedotin-piiq as a lyophilized powder in a single-dose vial for intravenous use. It is available by prescription only.

What are the common side effects of Polivy?

Common side effects of Polivy in patients with large B-cell lymphoma treated with Polivy in combination with R-CHP are constipation, peripheral neuropathy, fatigue, nausea, diarrhea, alopecia, and mucositis.

Common side effects of Polivy in patients with relapsed or refractory DLBCL treated with Polivy in combination with BR are neutropenia, thrombocytopenia, anemia, peripheral neuropathy, fatigue, diarrhea, pyrexia, decreased appetite, and pneumonia.

How much does Polivy cost in India?

Get the best Polivy cost in India. If you want to buy it online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price in India through legal channels.

How can I store Polivy?

Store refrigerated at 2 to 8°C (36 to 46°F) in the original carton to protect from light. Do not use beyond the expiration date printed on the carton. Do not freeze. Do not shake.

Is the Polivy injection Available In India?

Polivy is an imported medicine that is not readily available in India. It can be imported against a valid prescription and import permit. THE INDIAN PHARMA (TIP) can facilitate the supply of Polivy injections after fulfilling the legal requirement (if applicable). Please contact us via +919310090915 or TOLL-FREE: 1800-889-1064 or write to us at info@theindianpharma.com to buy Polivy online in India.

Can I get Polivy even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access/import Polivy (Polatuzumab Vedotin-piiq), not approved in their home country against the valid prescription and in conformity with local laws and regulations of their respective country.

Where can I get Polivy at the best price?

To get the best Polivy price in India and other countries, always buy this therapeutic drug from a Pharmaceutical Wholesaler Company that is GDP-certified. Noida-based THE INDIAN PHARMA (TIP) can offer the best price for Polivy (Polatuzumab Vedotin-piiq).

Is it safe to buy Polivy online in India?

Yes, one can buy Polivy injections online from India-based The Indian Pharma (TIP) if this therapeutic drug is not registered or is unavailable in the country. We can facilitate the supply of Polivy injections through legal channels.

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