Nublexa (Regorafenib)

  • Brand Name: NUBLEXA
  • Medicine Name: Regorafenib
  • Company Name: Bayer Zydus Pharma
  • Supplied as 28 tablets in one pack. Each tablet is 40mg.
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Description

NUBLEXA™ (Regorafenib) is a registered trademark of Bayer Zydus Pharma.

General warning: When observed in clinical trials, Regorafenib can cause severe fatal hepatotoxicity. The monitoring of hepatic function should be done during or after the treatment. If any elevation in liver enzymes or hepatocellular necrosis is found, then the rigorous dosage is reduced or discontinued depending upon the severity and persistence of the disease.

What is a Metastatic Colorectal Cancer?

Colorectal cancer is cancer that develops from the colon or rectum. It is also known as colon cancer, rectal cancer, or bowel cancer. Metastatic colorectal cancer spreads to two different parts of the body such as liver lungs or other organs. This cancer can also spread to the brain with the help of the spinal cord. The abundant widespread site of metastasis for colorectal cancer in the liver. Symptoms of colorectal cancer are weight loss, tiredness, bowel movement, blood in the stool.

Metastatic Colorectal Cancer Treatment: There are several treatment methods of metastatic colorectal cancer. Some of which are mentioned below:

  • Radiation therapy: Radiation therapy is performed to reduce the size of the tumor or to completely destroy the cancer cell.
  • Surgery: By surgery, tumors are removed from the liver and colon. This process reduces the pain and recovery time. If the tumor is big then Radiation therapy and chemotherapy are used to shrink the tumor before surgery.
  • Clinical trials: Several tests are performed under the clinical trials to wipe up the cancer cell.
  • Chemotherapy: chemotherapy is done before the surgery to shrink the size of the tumor. It can also be performed after surgery to wipe up all the remaining cancerous cells.
  • Targeted therapy: few targeted drugs are used to destroy the cancer cell by blocking its activity.
  • Immunotherapy: The immunotherapy body prepares its own cell to fight against cancer cells.

Regorafenib uses:

Regorafenib is a kinase inhibitor class drug used to treat metastatic colorectal cancer. This drug is used to treat patients who have previously received treatment with oxaliplatin, fluoropyrimidine and irinotecan-based chemotherapy.

More Info.

Regorafenib side effects: The most common side effect of Regorafenib is:




  • Loss of appetite

  • Asthenia

  • Hand-foot skin reaction

  • Diarrhea

  • Infection

  • Mucositis

  • Hypertension

  • Dysphonia


What is NUBLEXA ™?


NUBLEXA is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an antiVEGF therapy, and, if KRAS wild type, an anti-EGFR therapy.


How Nublexa tablet works: Nublexa is an anti-cancer medication that is used for the treatment of metastatic colorectal cancer treatment. Nublexa works by inhibiting the activity of an abnormal protein that signals the cancerous cell to multiply and divide. This blocking stops or slows down the spreading of the cancerous cell.


Dosage: Regorafenib is available in a film-coated tablet of concentration 40 mg. The recommended dose of regorafenib is 160 mg this medication is consumed orally for at least 21 days. Regorafenib is consumed with food.


Precaution: Few precautions of the FDA label regorafenib tablet are:




  • This medication is affected by any dermatological toxicity.

  • If the patient has hypertension, then this medication is avoided temporarily or permanently.

  • Discontinue the use of Regorafenib if the patient develops cardiac ischemia and infarction. The use of this medication is resumed once these events stop.

  • One should discontinue the administration of Regorafenib if the patient develops reversible posterior leukoencephalopathy syndrome.

  • In the case of gastrointestinal perforation, the use of this medication is stopped.

  • The use of this medication is not considered in the case of pregnancy. This can cause fetal damage as well as damage to the mother.


Interaction




  • Strong CYP3A4 inducers: Use of strong CYP3A4 inducers should be avoided.

  • Strong CYP3A4 inhibitors: Avoid strong CYP3A4 inhibitors.


Overdose: The highest dose a person can survive is 220 mg per day. The adverse overdose reactions observed are diarrhoea, mucosal inflammation, dermatological events, dysphonia, dry mouth, hypertension, fatigue, decreased appetite.


If any symptoms of overdose appear, then discontinue the administration of Regorafenib.

Missed dose: If a patient misses any dose then he should immediately consult a doctor. Taking doses at the wrong time may cause the severity of overdose toxicity.


Self-care Tips




  • Drink at least 324 liters of water every day.

  • Avoid going to crowded places as it may avoid the risk of infection.

  • Wash your hands properly.

  • Taking dental appointments must be avoided.

  • The use of any razor should be avoided as it may cause bleeding.

  • Any activity or sport that may result in injury must be avoided.

  • Minimize sun exposure.

  • Take at least 7 to 8 hours of sleep every day.

  • Eat nutritious food


Drugs Approved for Kidney (Renal Cell) Cancer




  • Afinitor (Everolimus)

  • Afinitor Disperz (Everolimus)

  • Aldesleukin.

  • SORANIB™ (Sorafenib 200 mg )

  • Avelumab.

  • SORAFENAT™ (Sorafenib 200mg )

  • Bavencio (Avelumab)

  • Bevacizumab.

  • CellCept Mycophenolate Mofetil

Commonly Asked Questions

What are the ingredients of the medicine NUBLEXA?


The active pharmaceutical ingredient in the medicine is Regorafenib monohydrate, and the inactive ingredients are cellulose microcrystalline, croscarmellose sodium, magnesium stearate, povidone, and colloidal silicon dioxide.


What is the best price for NUBLEXA?


You can ring us on +91 8130290915 for the NUBLEXA price in India


We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.


Where can I Buy NUBLEXA?


The Indian Pharma connects the buyer with the supplier who can ship NUBLEXA to any country of the world as per the buyer’s requirement and Government regulations of the co