Padcev (Enfortumab Vedotin)

  • Brand Name: Padcev
  • Innovator Brand Name: Padcev
  • API: Enfortumab Vedotin-ejfv
  • Dosage Form & Strength: For Injection: 20 mg and 30 mg of enfortumab vedotin-ejfv as a lyophilized powder in a single-dose vial for reconstitution
  • Manufacturer Name: Astellas Pharma US, Inc.
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Description

Padcev Medication

Padcev (Enfortumab Vedotin) is a Nectin-4-directed antibody and microtubule inhibitor conjugate used for the treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor, and a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced or metastatic setting.

Dosage: The recommended dose of Padcev is 1.25 mg/kg (up to a maximum of 125 mg for patients ≥100 kg) should be administered as an intravenous infusion over 30 minutes on Days 1, 8 and 15 of a 28-day cycle until the disease is progressive or unacceptable toxicity occurs.

Side Effects: The most commonly reported enfortumab vedotin side effects include:

  • Fatigue
  • Peripheral neuropathy
  • Decreased appetite
  • Rash
  • Alopecia
  • Nausea
  • Dysgeusia
  • Diarrhea
  • Dry eye
  • Pruritus and dry skin

Warnings and Precautions:

  • Closely monitor patients with enfortumab vedotin-ejfv 30 mg for blood glucose levels in patients with, or at risk for, diabetes mellitus or hyperglycemia.
  • Monitor patients for symptoms of new or worsening peripheral neuropathy and consider dose interruption or dose reduction of enfortumab vedotin when peripheral neuropathy occurs.
  • Padcev can cause fetal harm when administered to a pregnant woman. Females of reproductive potential are advised to use effective contraception during treatment with padcev 30 mg and for 2 months after the last dose.
  • Male patients with female partners of reproductive potential are advised to use effective contraception while on treatment with enfortumab vedotin and for four months following the last dose.
  • Due to the risk for serious adverse events in a breastfed child, lactating women are advised not to breastfeed while on treatment with padcev 20 mg and for at least 21 days after the last dose.

More info

Storage: Store Enfortumab Vedotin vials refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton. Neither freeze nor shake it. Availability in India: The Indian Pharma helps connect buyers with suppliers who can ship the PADCEV at the global level as per the needs of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the PADCEV Injections. Buying Procedure: In order to buy PADCEV, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +919650877511 or an Email to us at: info@theindianpharma.com along with the legitimate ID Proof, standard Prescription and Medical Reports. Conclusion: Enfortumab vedotin treatment demonstrated a clinically meaningful response rate (RR) with a manageable and tolerable safety profile in patients with locally advanced or metastatic urothelial carcinoma who have previously taken treated with platinum and anti-PD-1/L1 therapies.  

FAQ

What is Padcev? Padcev is an antibody-drug conjugate designed to treat cancer expressing Nectin-4. Padcev contains Enfortumab vedotin as an Active Ingredient. Enfortumab refers to the monoclonal antibody part, and vedotin refers to the payload drug (MMAE) and the linker. What does Padcev contain as an active substance? The medication Padcev specifically contains the active substance Enfortumab Vedotin. How is Enfortumab Vedotin supplied? Enfortumab Vedotin is supplied as Injections, 20 mg and 30 mg for intravenous infusion. How much does padcev cost? The padcev price in India usually can vary depending on the wholesaler/pharmacy you visit. Padcev is available as a brand name drug only, a generic version is not yet available. What is the best price for Enfortumab Vedotin? Please contact Toll-free: +91 1800 889 1064|+919650877511 for enfortumab vedotin price in India. We take the guarantee of quality and delivery anywhere in the world as per the buyer’s requirements. Can I get Padcev (Enfortumab Vedotin) even if I am not based in India? The Indian Pharma helps patients in accessing or importing Padcev (Enfortumab Vedotin), not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country.

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