(ORKAMBI is registered trademarks Vertex Pharmaceuticals Incorporated)
lumacaftor-ivacaftor used for: Orkambi is a fixed-dose combination medication comprising 200 mg lumacaftor and 125 mg ivacaftor, used for the treatment of cystic fibrosis (CF) in patients aged 6-years and older.
Dosage: Always take orkambi exactly as your healthcare practitioner has told you. The recommended orkambi dosage for patients aged 6-11 years and 12-years and older is 2-tablets in the morning, and 2-tablets in the evening (12 hours apart) as the strength of Orkambi 100 mg/125 mg and Orkambi 200 mg/125 mg respectively. That is a total of 4-tablets daily, to be taken through food containing fat.
Treatment Reactions: The most commonly reported orkambi side effects may include:
- Increase in sputum
- Common cold
- Cough with sputum
- Nasal congestion
- Shortness of breath
- Abdominal pain (stomach ache)
Warnings and precautions
- Avoid using lumacaftor/ivacaftor, in case you are allergic to this medicine, or any of it’s existing ingredients.
- Use of lumacaftor-ivacaftor tablet is not recommended in patients other than those who have a couple of copies of the F508del mutation in their CFTR gene.
- Discuss with your healthcare provider prior to taking lumacaftor and ivacaftor in case you’ve been told you have liver/kidney disease as the healthcare practitioner may need to adjust the dose of orkambi.
- Your healthcare practitioner should perform some blood tests in order to check your liver prior to and while taking the orkambi tablet, mainly during the initial year.
- An increase in blood pressure has been observed in certain patients treated with lumacaftor/ivacaftor. Your healthcare practitioner may monitor your blood pressure while on treatment with this medication.
- Use of orkambi is not recommended in those patients who have undergone an organ transplant.
- Use of lumacaftor and ivacaftor tablets should be avoided in children aged under 6 years.
- In case you’re pregnant or breast-feeding, think you may be pregnant, or want to have a baby, ask your healthcare professional for advice prior to taking this medication.