Acalabrutinib

  • Brand Name- Acabrunat
  • API- Acalabrutinib
  • Packaging: 30 Capsules
  • Strength: 100 mg
  • Manufacturer Name: Natco Pharma Ltd
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Description

Acabrunat (Acalabrutinib 100 mg) capsule, a kinase inhibitor is primarily used in the treatment of certain types of blood cancers. It is a targeted therapy that belongs to a class of medicines known as Bruton’s Tyrosine Kinase (BTK) inhibitors. Here’s a look at its uses:

  • Mantle Cell Lymphoma (MCL): Acalabrutinib 100 mg is used for the treatment of Mantle Cell Lymphoma, especially in adult patients who have already undergone at least one prior treatment. MCL is a rare and aggressive form of non-Hodgkin lymphoma, and this medicine works by interfering with the growth of cancer cells, slowing down or stopping their proliferation.
  • Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL): These are common types of leukemia in adults. Treatment with Acalabrutinib is used as a monotherapy or in combination with other medications to treat CLL and SLL. By targeting BTK, the drug helps in controlling the spread and multiplication of cancer cells, which can enhance the patient’s quality of life.

Overall, Acalabrutinib capsules offer a vital therapeutic option for patients with specific blood cancers by targeting and inhibiting the growth of cancerous cells. Patients taking this medicinal product should be under the care of a healthcare professional to monitor for efficacy and manage potential side effects.

Dosage and Side Effects

Acalabrutinib as Monotherapy: The recommended dosage for patients with MCL, CLL, or SLL is 100 mg taken orally approximately every 12 hours until there is evidence of disease progression or unacceptable toxicity.

Acalabrutinib in Combination with Obinutuzumab: The recommended dosage for patients with previously untreated CLL or SLL is 100 mg taken orally approximately every 12 hours until there is evidence of disease progression or unacceptable toxicity. Start treatment at Cycle 1 (each cycle is 28 days). Administer Acalabrutinib before obinutuzumab when given on the same day.

Swallow capsules whole with water without chewing or crushing. It may be taken with or without food. If a dose is missed by more than 3 hours, it should be skipped and the very next scheduled dose should be taken at its regularly scheduled time. Extra capsules should not be taken to make up for a missed dose. 

The most commonly reported side effects of Acalabrutinib capsules include anemia, upper respiratory tract infection, neutropenia, thrombocytopenia, diarrhea, headache, and musculoskeletal pain.

Warning and Precautions

  • Patients receiving treatment with this medication should be closely monitored for serious and opportunistic infections, such as bacterial, fungal, and viral infections. Prompt diagnosis and management are crucial. Patients should immediately report any signs of infection, including fever, chills, cough, or fatigue, to their healthcare provider.
  • Hemorrhage is a potential risk, especially for patients on anticoagulants. Watch for signs of unusual bleeding or bruising during treatment with Acabrunat 100 mg. It is essential to inform healthcare providers of any bleeding disorders or medications that could increase bleeding risk before starting treatment.
  • Cytopenias, including neutropenia, thrombocytopenia, and anemia, may occur. Regular blood counts should be conducted to monitor for hematologic changes. Patients receiving treatment with this therapeutic drug should report symptoms like persistent fatigue, easy bruising, or bleeding.
  • Patients treated with certain therapies may have an increased risk of developing second primary malignancies, including skin cancer. Regular skin examinations and preventive measures are recommended while on treatment with Acabrunat capsules.
  • Cardiac arrhythmias, including atrial fibrillation, may occur. Patients with a history of heart disease should be monitored closely. Symptoms such as palpitations, dizziness, or chest pain should be reported promptly.
  • Hepatotoxicity, including drug-induced liver injury, may occur. Regular liver function tests should be performed. Signs of liver issues, such as jaundice, dark urine, or abdominal pain, require immediate medical attention.
  • This medication is not recommended during pregnancy due to potential harm to the fetus. Women of childbearing potential should use effective contraception. It is also advised to avoid breastfeeding during treatment due to potential risks to the infant.

FAQ's

What is the active substance in Acabrunat?

Acalabrutinib is the active substance in Acabrunat.

How is Acalabrutinib supplied?

Acalabrutinib is supplied as a Capsule: 100 mg for oral use/administration.

How much does Acalabrutinib cost?

Please Call/WhatsApp: +91 8130290915 or dial our TOLL-FREE: 1800-889-1064 to get the exact cost of Acalabrutinib 100 mg Capsules. If you want to buy Acalabrutinib online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price through legal channels.

Is Acalabrutinib Available In India?

Acalabrutinib is a pharmaceutical prescription medicinal product that can only be dispensed against a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of this medicine to all locations after fulfilling the legal requirement (if applicable). Please contact us via +91 8130290915 | TOLL-FREE: 1800-889-1064 or write us at info@theindianpharma.com to buy generic Acalabrutinib from India at the best price.

Can I get Acalabrutinib even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access generic Acalabrutinib, not approved in their home country against a valid prescription and in conformity with their respective country’s local laws and regulations.

Where can I get Acalabrutinib at the best price?

To get the best Acalabrutinib price from India, always buy this therapeutic drug from a GDP-certified Pharmaceutical Wholesaler Company. Noida-based THE INDIAN PHARMA (TIP) can offer the best price for Generic Acalabrutinib.

Is it safe to buy generic Acalabrutinib online from India?

Yes, one can buy Acalabrutinib 100 mg online at the best price from THE INDIAN PHARMA (TIP) if this medicine is not registered or is unavailable in their country. TIP can help facilitate the supply of generic Acalabrutinib through legal channels.

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