Thiotepa Injection

Facts of Medicine

  • Innovator Brand Name: Tepadina
  • Medicine Name- Thiomed
  • API- Thiotepa
  • Packaging- 1 Vial/Box 
  • Strength- 15 mg and 100 mg
  • Manufactured by- Mediclone
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Uses of medication:  Thiotepa injection is a alkylating agent, supplied generically under the brand Thiomed. This therapeutic drug is used:

  • To reduce the risk of graft rejection when used along with high-dose busulfan and cyclophosphamide as a preparative regimen for allogeneic hematopoietic progenitor (stem) cell transplantation (HSCT) for pediatric patients with class 3 beta-thalassemia.
  • For treatment of adenocarcinoma of the breast or ovary.
  • For controlling intracavitary effusions secondary to diffuse or localized neoplastic diseases of various serosal cavities.
  • For treatment of superficial papillary carcinoma of the urinary bladder.

Dosage and Side Effects

The recommended dose of Thiotepa injection for class 3 beta-thalassemia is two administrations of 5 mg/kg given intravenously (IV) approximately 12 hours apart on Day -6 before allogeneic HSCT along with high-dose busulfan and cyclophosphamide. 

The recommended dose of Thiotepa for the treatment of adenocarcinoma of the breast or ovary is 0.3 to 0.4 mg/kg administered intravenously.

The recommended dose of Thiotepa for the treatment of malignant effusions is 0.6 mg/kg to 0.8 mg/kg intracavitary.

The recommended dose of Thiotepa for the treatment of superficial papillary carcinoma of the urinary bladder is 60 mg in 30 to 60 mL of Sodium Chloride Injection into the bladder by catheter. 

The most common side effects of Thiotepa injection are hemorrhage, diarrhea, neutropenia, elevated alanine aminotransferase, anemia, thrombocytopenia, elevated aspartate aminotransferase, elevated bilirubin, mucositis, cytomegalovirus infection, hematuria, and rash.

Warning and Precautions

  • The consequence of therapy with high doses of Thiotepa along with other chemotherapy at the prescribed dose and schedule in the preparative regimen for class 3 beta- thalassemia is profound myelosuppression occurring in all patients. Avoid beginning the preparative regimen if a stem cell donor does not exist. Monitor complete blood counts (CBC), and provide supportive care for infections, anemia and thrombocytopenia until there is sufficient hematopoietic recovery. 
  • For those receiving Thiotepa for treatment of adenocarcinoma of the breast, adenocarcinoma of the ovary, malignant effusions, and superficial papillary carcinoma of the urinary bladder, if the bone marrow has been compromised by prior irradiation or chemotherapy, or is recovering from chemotherapy, the risk of severe myelosuppression with Thiotepa may be increased. Perform periodic complete blood counts (CBC) during the course of treatment. Provide supportive care for bleeding, infections, and symptomatic anemia.
  • Clinically significant hypersensitivity reactions, including anaphylaxis, may occur following the use of Thiotepa. In case of anaphylactic or other clinically significant allergic reactions, stop therapy, initiate suitable therapy, and monitor patients until signs and symptoms resolve.
  • Skin reactions linked with accidental exposure to Thiotepa treatment may develop. Wash the skin thoroughly with the help of soap and water in case Thiotepa solution contacts the skin. Flush mucous membranes in case of medicine contact with mucous membranes.


What is the active substance in Thiomed?

Thiotepa is the active substance in Thiomed.

How is Thiotepa supplied?

Thiotepa is supplied in the form of Injection: 15 mg and 100 mg in a single-dose vial for intravenous (IV) use.

How much does Thiotepa cost?

Please Call/WhatsApp: +91 8130290915 or dial our TOLL-FREE: 1800-889-1064 to get the latest Thiotepa 15 mg/100 mg injection cost. If you want to buy Thiotepa injection online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price through legal channels.

Is Thiotepa Available In India?

Thiotepa injection is a pharmaceutical prescription medicinal product that can be only dispensed against a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of Thiotepa injection to all locations after fulfilling the legal requirement (if applicable). Please contact us via +91 8130290915 | TOLL-FREE: 1800-889-1064 or write us at to buy generic Thiotepa injection at the best price.

Can I get Thiotepa even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access Thiotepa injection, not approved in their home country against the valid prescription and in conformity with the local laws and regulations of their respective country.

Where can I get Thiotepa at the best price?

To get the best Thiotepa injection price from India, always buy this medicine from a Pharmaceutical Wholesaler Company that is GDP-certified. Noida-based THE INDIAN PHARMA (TIP) can offer the best price for Generic Thiotepa injection.

Is it safe to buy generic Thiotepa online from India?

Yes, one can buy Thiotepa 15 mg/100 mg injection online at the best price from THE INDIAN PHARMA (TIP) if this medicine is not registered or is unavailable in their country. TIP can help facilitate the supply of generic Thiotepa injection through legal channels.