Nirmatrelvir/Ritonavir

 

  • Brand Name – Paxlovid
  • API: Nirmatrelvir/Ritonavir
  • Packaging:  Co-packaged tablets for oral use
  • Strength:150 mg/100 mg
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Description

Nirmatrelvir/Ritonavir Uses:

Nirmatrelvir/Ritonavir is a co-packaged oral medicine, authorized for the treatment of mild-to-moderate COVID-19 in adults (12 years of age and older and weighing at least 40 kg or 88 lbs) with positive results of direct SARS-CoV-2 viral testing, and who are at an increased risk for progression to severe COVID-19 disease, including hospitalization or death. As an antiviral monotherapy (Nirmatrelvir Ritonavir), it is active against SARS-CoV-2, including Alpha, Beta, Gamma, Delta, and Omicron variants of concern, but not authorized:

  • for use in those requiring hospitalization due to severe or critical COVID-19.

  • for pre/post-exposure prophylaxis for the prevention of COVID-19.

  • for use beyond five consecutive days.

Note: Nirmatrelvir/Ritonavir has an Emergency Use Authorisation (EUA) from the US Food and Drug Administration.

Dosage:

Nirmatrelvir tablets co-packaged with ritonavir tablets. Nirmatrelvir must be used with ritonavir. Failure to precisely co-administer nirmatrelvir with ritonavir may result in plasma levels of nirmatrelvir that will be not sufficient to get the desired therapeutic effect.

The recommended dosage is 300 mg nirmatrelvir (two 150 mg tablets) with 100 mg ritonavir (one 100 mg tablet) with all 3 tablets taken together by mouth (orally) twice daily for 5 consecutive days. Patients must finish the complete 5-day treatment course. The route of administration of Nirmatrelvir Ritonavir tablet is oral (by mouth). The proposed tablets should be swallowed whole and not be broken, chewed, opened, or crushed for dispersion.

Treatment with this antiviral FDC medicine should be started as quickly as possible after positive results of direct SARS-CoV-2 viral testing and within five days of symptom onset.

Side Effects:

Typically side effects are minimal and temporary. The most commonly reported Nirmatrelvir and Ritonavir side effects are:

  • Diarrhea
  • muscle pain
  • high blood pressure
  • change in sense of taste

Warnings and Precautions:

  • Initiation of nirmatrelvir/ritonavir, a CYP3A inhibitor, in those taking medicines metabolized by CYP3A or initiation of medicines metabolized by CYP3A in those already taking this antiviral, may rise plasma concentrations of medicines metabolized by CYP3A. Initiation of drugs that block or induce CYP3A may rise or decline the concentrations of nirmatrelvir/ritonavir, respectively.

  • Anaphylaxis and certain other hypersensitivity reactions may occur with nirmatrelvir/ritonavir. Cases of Toxic Epidermal Necrolysis and Stevens-Johnson syndrome may be reported with ritonavir, a component of this medicinal product. If signs/symptoms of a clinically significant hypersensitivity reaction or anaphylaxis occur, promptly discontinue treatment and initiate suitable medicines or supportive care.

  • Hepatic transaminase elevations, clinical hepatitis, and jaundice may occur in patients receiving ritonavir. Therefore, precise caution must be considered when administering Nirmatrelvir 150 mg and Ritonavir 100 mg Tablets to patients with pre-existing liver complications, liver enzyme abnormalities, or hepatitis.

  • Because nirmatrelvir 150 mg is co-administered with ritonavir 100 mg, there may be a risk of human immunodeficiency virus-1 establishing resistance to HIV protease inhibitors in all those with undiagnosed or uncontrolled HIV-1 infection.

  • Women of childbearing age should use relevant contraception during nirmatrelvir and ritonavir treatment. The use of ritonavir may decline the efficacy of combined hormonal contraceptives. Those using combined hormonal contraceptives should use an apt alternative contraceptive method or an additional barrier method of contraception during treatment.

More Info

Storage:

Store nirmatrelvir and ritonavir tablets at room temperature (20-25°C). Store in a well-closed container, away from moisture, excess heat, and direct light. Keep this medicinal product from freezing.

Availability in India:

The Indian Pharma helps connect buyers with suppliers who can ship Nirmatrelvir and Ritonavir Tablets at the global level as per the need of buyers. The Indian Pharma (TIP) provides a guarantee of quality and delivery for the Nirmatrelvir and Ritonavir Tablets.

Buying Procedure:

In order to buy Nirmatrelvir and Ritonavir, you can contact us at our TOLL-FREE Number: 800 889 1064 or on WhatsApp: +91 8130290915 or Email us at: info@theindianpharma.com along with your Identity Proof, Valid Prescription Letter, and Medical Reports.

Conclusions:

In conclusion, early administration of oral nirmatrelvir and ritonavir therapy may effectively reduce the risk of COVID-19-related hospitalization or death.

FAQ

Who is Nirmatrelvir/ritonavir recommended for?

Nirmatrelvir/ritonavir is recommended for adults/pediatric patients aged 12 years and older weighing at least 40 kg with positive SARS-CoV-2 test results who are at an increased risk for progression to serious disease.

What does nirmatrelvir and ritonavir do?

Nirmatrelvir and ritonavir fixed-dose combination is used to treat mild to moderate COVID-19 disease in those who are at higher for developing a serious illness. This medicine is available only with your treating physician’s prescription.

Did FDA approve nirmatrelvir/ritonavir?

Antiviral Nirmatrelvir/ritonavir is authorized for emergency use by the US FDA to treat mild-to-moderate COVID-19 in adults and pediatric patients (aged 12 years and older weighing at least 40 kg) who are at a greater-risk for progression to serious COVID-19 infection.

How much does Nirmatrelvir/Ritonavir cost?

>Nirmatrelvir/Ritonavir cost in India is less and can vary. To procure this antiviral authentically, you can get in touch with us either via TOLL-FREE: 1800 889 1064 or Call/WhatsApp: +91 8130290915 or Email: info@theindianpharma.com.

Where can I get Nirmatrelvir/Ritonavir at the best price?

The Indian Pharma, an ISO and WHO-GDP certified Pharmaceutical Wholesaler Company is offering the best Nirmatrelvir/Ritonavir price. Nirmatrelvir/Ritonavir is a co-packaged oral antiviral medicinal product.

Can I get Nirmatrelvir/Ritonavir even if I am not based in India?

The Indian Pharma helps patients in accessing or importing Nirmatrelvir/Ritonavir, not approved in their home country against the legitimate prescription and in conformity with all local laws and regulations of their home country.

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