Nitisinone Capsules

Fact of Medicine:

  • Innovator Brand Name: Orfadin
  • Medicine Name: Lasinone
  • API: Nitisinone
  • Packaging: 60 Capsules
  • Strength: 2 mg/5 mg/10 mg
  • Manufacturer Name: Laurus Labs Ltd
Get Price


Uses of medication: 

Nitisinone capsule is a hydroxy-phenylpyruvate dioxygenase used in the treatment of adult and pediatric patients (in any age range) with a confirmed diagnosis of HT-1 (Hereditary tyrosinemia type 1) in conjunction with dietary restriction of tyrosine and phenylalanine.

Dosage: The recommended starting dosage of Nitisinone capsules is 0.5 mg/kg administered orally twice daily at least 1 hour before, or 2 hours after a meal.

Maintenance Regimen: In individuals aged five years and more who have not detectable serum as well as urine succinylacetone concentrations following at least 4 weeks on a stable treatment with nitisinone, the total daily nitisinone capsule dose may be given once daily (e.g., 1 mg/kg to 2 mg/kg once daily).

Dosage Titration: The dosage can be titrated in each patient on behalf of biochemical response and/or clinical response. Monitor plasma or urine succinylacetone concentrations, alpha-fetoprotein levels, and liver function parameters. If succinylacetone is still detectable in urine or blood 4 weeks after the beginning of nitisinone therapy, increase the dosage of nitisinone capsule to 0.75 mg/kg twice daily. A maximum total daily dosage of 2 mg/kg may be required on behalf of the evaluation of all biochemical parameters.

Treatment Reactions: The most commonly reported side effects of Nitisinone 2mg/5mg/10mg capsules are:

  • Elevated tyrosine levels
  • Thrombocytopenia
  • Leukopenia
  • Conjunctivitis
  • Corneal opacity
  • Keratitis
  • Photophobia
  • Eye pain
  • Blepharitis
  • Cataracts
  • Granulocytopenia
  • Pruritus
  • Epistaxis
  • Exfoliative dermatitis
  • Dry skin
  • Maculopapular rash
  • Alopecia

Warnings and Precautions:

  • The slit-lamp examination needs to be performed prior to Nitisinone 10 mg capsule therapy and thereafter regularly, at least yearly. A patient with visual disorders during treatment without delay be examined by an ophthalmologist.
  • Monitor should liver function regularly by liver function tests and liver imaging. It is prescribed to also assess serum alpha-fetoprotein concentrations. An elevation in serum alpha-fetoprotein concentration may indicate inadequate therapy. Those with elevated alpha-fetoprotein or signs of nodules in the liver need to be assessed for hepatic malignancy.
  • There are reports that patients treated with Lasinone capsules and dietary restrictions developed transient leucopenia, thrombocytopenia, or both. One patient who developed Leucopenia and thrombocytopenia improved after the dose of Lasinone decreased from 2-1 mg/kg. No patients developed infections or bleeding due to the episodes of Leucopenia and thrombocytopenia. One should regularly monitor platelet and white blood cell counts (WBCs) during nitisinone therapy.
  • There are no satisfactory data on the use of nitisinone in the pregnant population. Studies in animals have demonstrated reproductive toxicity. The probable risk for humans is not known. Do not use Nitisinone during pregnancy unless the clinical condition of the respective patient needs this treatment.
  • It is not known whether this drug is excreted in breast milk (human). Animal findings have demonstrated adverse postnatal effects via exposure to nitisinone in milk. So Therefore, those on Treatment of Tyrosinemia type 1 with nitisinone capsules must avoid breastfeeding, since the risk to the suckling child cannot be excluded.
  • Nitisinone capsule has minimal influence on the potential to drive and use machinery. Certain side effects involving the eyes may affect the vision. In case of affected vision, the respective patient must avoid driving or using any machinery until the complication has subsided.

More info

Storage: Store refrigerated at 2-8 °C (36-46 °F). Alternatively, patients or caregivers may store Nitisinone capsules at room temperature up to 25°C (77°F) for up to 45 days. If not used within 45 days, discard the capsules.

Availability in India: The Indian Pharma (TIP) helps connect buyers with suppliers who can ship Nitisinone at the global level as per the need of buyers. The Indian Pharma (TIP) provides the guarantee of quality and delivery for the Nitisinone Capsules.

Buying Procedure: In order to buy Nitisinone online, you can contact us at our TOLL-FREE: 1800 889 1064 or on WhatsApp Number +91 8130290915 or Email us at: along with your Identity Proof, Prescription Letter, and Medical Reports.

Conclusion: Nitisinone is effective as an adjunct to dietary restriction of tyrosine and phenylalanine for the treatment of Hereditary tyrosinemia type 1 (HT-1).


What is the active substance in Lasinone capsules?

Nitisinone is the active substance in medicine Lasinone capsules.

What is Nitisinone used in the treatment of?

Healthcare professionals recommend Nitisinone as an adjunct to dietary restriction of tyrosine and phenylalanine in treating patients with hereditary tyrosinemia type 1 (HT-1).

How is Nitisinone supplied?

Nitisinone is supplied in the form of capsules for oral use/administration. It is commercially available in 2 mg, 5 mg, and 10 mg by prescription only.

How much does Nitisinone cost?

Call/WhatsApp: +91 8130290915 or dial our TOLL-FREE: 1800-889-1064 to get the latest Nitisinone cost. If you want to buy Nitisinone capsules online, then THE INDIAN PHARMA (TIP) can help you to access this medicinal product at the most competitive price through legal channels.

Is the Nitisinone Capsule Available In India?

Nitisinone is a pharmaceutical prescription medicinal product that can be only dispensed against a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of Nitisinone to all locations after fulfilling the legal requirement (if applicable). Please contact us via +91 8130290915 | TOLL-FREE: 1800-889-1064 or write us at to buy Nitisinone from India.

Where can I get Nitisinone Capsules at the best price?

In order to get the best Nitisinone capsule price in India and other countries, always buy this drug from a Pharmaceutical Wholesaler Company which is GDP certified. Noida-based THE INDIAN PHARMA (TIP) can offer the best Nitisinone price.

Is it safe to buy Nitisinone online from India?

Yes, one can buy Nitisinone online at the best price from The Indian Pharma (TIP) if the drug Nitisinone is not registered or is unavailable in their country. We can help facilitate the supply of Nitisinone through legal channels.

How THE INDIAN PHARMA (TIP) can help in accessing Nitisinone?

THE INDIAN PHARMA (TIP) has authorization to supply Nitisinone manufactured by Laurus Labs. Kindly get in touch with us today to buy and find the latest Nitisinone price in India. Nitisinone capsules in India can be made available through the network of authorized distributors (in Ahmedabad, Kolkata, Chennai, Hyderabad, Mumbai, Delhi, Bangalore, Pune, etc.)

Can You Send the medicine Nitisinone to Foreign Destinations?

Buy Nitisinone generic medicine online from a leading supplier online at the best/lowest price in India. The Indian Pharma can assist in the delivery of this medicine, doctor-prescribed medication to the USA, UK, Canada, Australia, China, Saudi Arabia, Thailand, South Africa, Zambia, Pakistan, Qatar, Kuwait, Sweden, Hong Kong, UAE, Philippines, Kazakhstan, Turkey, Singapore, Malaysia, Sri Lanka, Uzbekistan Afghanistan, Nepal, Japan, and many more countries.