Xpovio (selinexor)

  • Brand Name: Xpovio
  • Innovator Brand Name: Xpovio
  • API: Selinexor
  • Dosage Form: 32 Tablets
  • Strength: 20mg
  • Manufacturer Name: Karyopharm Therapeutics.
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Xpovio Medication

Xpovio (Selinexor) is a nuclear export inhibitor used in combination with dexamethasone to treat adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two PIs, at least two immunomodulatory agents, and an anti‐CD38 monoclonal antibody.

Dosage: The recommended starting dosage of selinexor is 80 mg (four 20 mg tablets) taken orally on Days 1 and 3 of each week until the disease is progressive or unacceptable toxicity occurs. The recommended starting dosage of dexamethasone is 20 mg taken orally with each dose of selinexor on Days 1 and 3 of each week. Each selinexor dose should be taken at around the same time of day, and each tablet should be swallowed whole with water. Do not break, chew, crush, or divide the pills. In case a dose of selinexor is missed or delayed, instruct patients to take their next dose at the next regularly scheduled time. If a patient vomits a dose of selinexor, do not repeat the dose and the patient should take the next dose on the next regularly scheduled day.

Side Effects: The most commonly reported xpovio side effects include:

  • Thrombocytopenia
  • Fatigue
  • Nausea
  • Anemia
  • Decreased appetite
  • Decreased weight
  • Diarrhea
  • Vomiting
  • Hyponatremia
  • Neutropenia
  • Leukopenia
  • Constipation
  • Dyspnea
  • Upper respiratory tract infection

Warnings and Precautions:

  • Monitor patients with xpovio tablets for signs/symptoms of concomitant infection and evaluate promptly.
  • Monitor patients for complete blood count, standard blood chemistry, and body weight at baseline and during therapy. Monitor more frequently during the initial 2 months of therapy.
  • Patients are advised to maintain the adequate fluid and caloric intake throughout the therapy with selinexor tablets. Intravenous hydration can be considered for patients at the risk of dehydration.
  • Provide the prophylactic concomitant treatment with a 5‐HT3 antagonist or other anti‐nausea agents prior to and while on treatment with selinexor.
  • Verify the pregnancy status of females of reproductive age before initiating selinexor 20 mg. As it can cause fetal harm if administered to a pregnant woman.
  • Because of the risk for serious adverse events in a breastfed child, women are advised to not breastfeed while on the xpovio dose and for 1 week after the last dose.

More info

Storage: Store Selinexor at or below 86°F (30°C). Selinexor comes in a child-resistant blister pack. Keep Selinexor and all medicines out of the reach of children. Availability in India: The Indian Pharma helps connect buyers with suppliers who can ship the XPOVIO at the global level as per the needs of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the XPOVIO Tablets. Buying Procedure: In order to buy XPOVIO, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +919310090915 or an Email to us at: info@theindianpharma.com along with the legitimate ID Proof, standard Prescription and Medical Reports. Conclusion: Selinexor-based regimens provide a novel approach to patients with RRMM. Sd is specifically important for recipients with no other therapeutic choices, including those previously taken treatment with novel cellular treatments.


What is Xpovio? Xpovio is a selective inhibitor of nuclear export recommended as an anti-cancer medication. It works by inhibiting the mechanism of exportin 1 and thus inhibiting the transport of multiple proteins existing in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests the cell cycle and leads to apoptosis. Xpovio is the first medication with this mechanism of action. What does Xpovio contain as an active substance? The medication Xpovio specifically contains the active substance Selinexor. How is Selinexor supplied? Selinexor is supplied as Tablets, 20 mg for orally administration. How much does xpovio cost? The xpovio price in India usually can vary depending on the wholesaler/pharmacy you visit. Xpovio is available as a brand name drug only, a generic version is not yet available. What is the best price for Selinexor? Please contact Toll-free: +91 1800 889 1064|+919310090915 for selinexor price in India. We take the guarantee of quality and delivery anywhere in the world as per the buyer’s requirements. Can I get Xpovio (Selinexor) even if I am not based in India? The Indian Pharma helps patients in accessing or importing Xpovio (Selinexor), not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country.