Description
Uses of Medicine:
Methotrexate 50 mg/2 mL & 1 gm/40 mL is a group of medicines called a folate analog metabolic inhibitor. Patients, Healthcare Professionals (HCP), or Hospitals can buy Methotrexate 50 mg/2 mL or 1 gm/40 mL Injections online from India through THE INDIAN PHARMA (a trusted Methotrexate Supplier, Exporter, and Contract Manufacturer in India) for the treatment and management:-
- Breast cancer
- Rheumatoid arthritis
- Polyarticular juvenile idiopathic arthritis
- Refractory psoriasis
- Acute lymphoblastic leukemia
- Relapsed or refractory non-Hodgkin lymphoma
- Head and neck squamous cell carcinoma
- Meningeal leukemia
- Osteosarcoma
- Gestational trophoblastic neoplasia
- Cutaneous T-cell lymphoma (mycosis fungoides)
Methotrexate 50 mg/1 gm Injection is a medicine widely used for treating certain types of cancer and some serious non-cancer conditions. It falls under the group of medicines called anti-metabolites and also works as an immunosuppressant. It helps block the progression of unhealthy cells in diseases such as acute lymphocytic leukemia (ALL), meningeal leukemia, non-Hodgkin lymphoma (NHL), osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer. It is also used for managing severe psoriasis, a skin condition with red and scaly patches. In addition, it is given to adults with rheumatoid arthritis (RA), a disease that causes joint swelling and pain.
Allergic reaction to Methotrexate 50 mg/1 gm injection or any of its components would contraindicate you from taking this medicine. Furthermore, a person with existing liver or kidney issues, blood disorders, autoimmune diseases, or an immunodeficient system is also unsuitable for this medication. This injection is not recommended for use in pregnant or lactating women because of the potential serious side effects on the child. Contact your doctor if you feel symptoms such as blood-tinged sputum, extreme muscle weakness, eyesight problems, disorientation or confusion, and cognitive problems. Patients should also know that this medication can impact fertility; they should avoid conceiving during treatment and for 6 months after the final dose.
Regarding medical history, tell your clinician about active infections, stomach ulcers, or mild kidney problems before initiating treatment with Methotrexate. Inform them about any recent or upcoming vaccinations. As previously stated, regular medical checkups and lab tests during treatment are essential because Methotrexate may result in severe side effects, even at low dosages.
Always follow your healthcare practitioner’s advice carefully. Never take this medicine without a valid prescription. It is necessary to understand the risks and take the necessary precautions while using Methotrexate 50 mg/1 gm Injection for safe and effective treatment.
Dosage & Side Effects:
Recommended Dosage for Acute Lymphoblastic Leukemia: The recommended dosage varies from 10 to 5000 mg/m2 intravenously. For high-dose Methotrexate Injection regimens, use leucovorin rescue. Lower doses (e.g., 20 to 30 mg/m2 /week) may be used intramuscularly. Recommended Dosage for Meningeal Leukemia: The recommended intrathecal dose of Methotrexate Injection (preservative-free) is based on age:- less than 1 year: 6 mg
- 1 to less than 2 years: 8 mg
- 2 to less than 3 years: 10 mg
- 3 to less than 9 years: 12 mg
- greater than or equal to 9 years: 12 to 15 mg.
Recommended Dosage for Non-Hodgkin Lymphoma: The recommended dosages of Methotrexate injection may vary based on treatment type. As a single agent, doses range from 5 to 75 mg IV for cutaneous forms and up to 8,000 mg/m² IV for central nervous system-directed therapy. In combination regimens, typical doses include 1,000 to 3,000 mg/m² IV over 24 hours or 3,000 to 8,000 mg/m² IV over 4 hours, followed by leucovorin rescue under high-dose methotrexate protocols.
Recommended Dosage for Osteosarcoma: The recommended dosage of Methotrexate is typically 12 g/m2 (maximum 20 g/dose) as an intravenous infusion over 4 hours, administered as a component of a combination chemotherapy regimen.
Recommended Dosage for Breast Cancer: A recommended dosage of Methotrexate is 40 mg/m2 intravenously as a component of a cyclophosphamide- and fluorouracil-based multi-drug regimen.
Recommended Dosage for Squamous Cell Carcinoma of Head and Neck: The recommended dosage of Methotrexate ranges from 40 to 60 mg/m2 intravenously once weekly.
Recommended Dosage for Gestational Trophoblastic Neoplasia: The recommended dosage for Methotrexate (in low-risk gestational trophoblastic neoplasia patients) is 30 mg/m2 to 200 mg/m2 or 0.4 mg/kg to 1 mg/kg intravenously (IV) or intramuscularly (IM). The recommended dosage for Methotrexate (in high-risk GTN patients) is 300 mg/m2 over 12 hours as an intravenous (IV) infusion as a component of a multi-drug regimen.
Recommended Dosage for Rheumatoid Arthritis: The recommended starting dosage of Methotrexate is 7.5 mg once weekly, administered intramuscularly (IM) with escalation to achieve optimal response. Dosages of 20 mg once weekly result in an increased risk of side effects, including myelosuppression.
Recommended Dosage for Polyarticular Juvenile Idiopathic Arthritis: The recommended starting dosage of Methotrexate is 10 mg/m2 once weekly administered subcutaneously (SC) or intramuscularly (IM), with escalation to achieve optimal response.
Recommended Dosage for Psoriasis: The recommended dosage of Methotrexate is 10 mg to 25 mg intramuscularly (IM) or intravenously (IV) once weekly until adequate response is achieved.
The most common side effects of Methotrexate 50 mg/1 gm oral Injections are changes in the womb, headache, feeling lightheaded, itching of the area around the vagina, hair loss, vomiting, diarrhoea, constipation, increase in risk of blood clots, leg cramp, muscle pain, and fatty liver.