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METHOTREXATE INJECTION

Methotrexate 50 MG/1GM Injections

Facts of METHOTREXATE

  • Medicine Name: Methotrexate  
  • API: Methotrexate
  • Packaging & Strength: Injections: 50 mg/2 mL & 1 gm/40 mL
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Description

Uses of Medicine:

Methotrexate 50 mg/2 mL & 1 gm/40 mL is a group of medicines called a folate analog metabolic inhibitor. Patients, Healthcare Professionals (HCP), or Hospitals can buy Methotrexate 50 mg/2 mL or 1 gm/40 mL Injections online from India through THE INDIAN PHARMA (a trusted Methotrexate Supplier, Exporter, and Contract Manufacturer in India) for the treatment and management: 
    • Breast cancer
    • Rheumatoid arthritis
    • Polyarticular juvenile idiopathic arthritis
    • Refractory psoriasis 
    • Acute lymphoblastic leukemia
    • Relapsed or refractory non-Hodgkin lymphoma
    • Head and neck squamous cell carcinoma 
    • Meningeal leukemia
    • Osteosarcoma 
    • Gestational trophoblastic neoplasia
  • Cutaneous T-cell lymphoma (mycosis fungoides)

Methotrexate 50 mg/1 gm Injection is a medicine widely used for treating certain types of cancer and some serious non-cancer conditions. It falls under the group of medicines called anti-metabolites and also works as an immunosuppressant. It helps block the progression of unhealthy cells in diseases such as acute lymphocytic leukemia (ALL), meningeal leukemia, non-Hodgkin lymphoma (NHL), osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer. It is also used for managing severe psoriasis, a skin condition with red and scaly patches. In addition, it is given to adults with rheumatoid arthritis (RA), a disease that causes joint swelling and pain.

Allergic reaction to Methotrexate 50 mg/1 gm injection or any of its components would contraindicate you from taking this medicine. Furthermore, a person with existing liver or kidney issues, blood disorders, autoimmune diseases, or an immunodeficient system is also unsuitable for this medication. This injection is not recommended for use in pregnant or lactating women because of the potential serious side effects on the child. Contact your doctor if you feel symptoms such as blood-tinged sputum, extreme muscle weakness, eyesight problems, disorientation or confusion, and cognitive problems. Patients should also know that this medication can impact fertility; they should avoid conceiving during treatment and for 6 months after the final dose.

Regarding medical history, tell your clinician about active infections, stomach ulcers, or mild kidney problems before initiating treatment with Methotrexate. Inform them about any recent or upcoming vaccinations. As previously stated, regular medical checkups and lab tests during treatment are essential because Methotrexate may result in severe side effects, even at low dosages.

Always follow your healthcare practitioner’s advice carefully. Never take this medicine without a valid prescription. It is necessary to understand the risks and take the necessary precautions while using Methotrexate 50 mg/1 gm Injection for safe and effective treatment.

 

Dosage & Side Effects:

Recommended Dosage for Acute Lymphoblastic Leukemia: The recommended dosage varies from 10 to 5000 mg/m2 intravenously. For high-dose Methotrexate Injection regimens, use leucovorin rescue. Lower doses (e.g., 20 to 30 mg/m2 /week) may be used intramuscularly. Recommended Dosage for Meningeal Leukemia: The recommended intrathecal dose of Methotrexate Injection (preservative-free) is based on age:
  • less than 1 year: 6 mg
  • 1 to less than 2 years: 8 mg
  • 2 to less than 3 years: 10 mg
  • 3 to less than 9 years: 12 mg
  • greater than or equal to 9 years: 12 to 15 mg.

For meningeal leukemia, intrathecal methotrexate may be administered at intervals of 2 or more days up to twice weekly. For meningeal leukemia prophylaxis, this therapeutic drug is administered no more than once weekly. For patients with Down Syndrome, administer leucovorin rescue with intrathecal Methotrexate Injection.

Recommended Dosage for Non-Hodgkin Lymphoma: The recommended dosages of Methotrexate injection may vary based on treatment type. As a single agent, doses range from 5 to 75 mg IV for cutaneous forms and up to 8,000 mg/m² IV for central nervous system-directed therapy. In combination regimens, typical doses include 1,000 to 3,000 mg/m² IV over 24 hours or 3,000 to 8,000 mg/m² IV over 4 hours, followed by leucovorin rescue under high-dose methotrexate protocols.

Recommended Dosage for Osteosarcoma: The recommended dosage of Methotrexate is typically 12 g/m2 (maximum 20 g/dose) as an intravenous infusion over 4 hours, administered as a component of a combination chemotherapy regimen.

Recommended Dosage for Breast Cancer: A recommended dosage of Methotrexate is 40 mg/m2 intravenously as a component of a cyclophosphamide- and fluorouracil-based multi-drug regimen.

Recommended Dosage for Squamous Cell Carcinoma of Head and Neck: The recommended dosage of Methotrexate ranges from 40 to 60 mg/m2 intravenously once weekly.

Recommended Dosage for Gestational Trophoblastic Neoplasia: The recommended dosage for Methotrexate (in low-risk gestational trophoblastic neoplasia patients) is 30 mg/m2 to 200 mg/m2 or 0.4 mg/kg to 1 mg/kg intravenously (IV) or intramuscularly (IM). The recommended dosage for Methotrexate (in high-risk GTN patients) is 300 mg/m2 over 12 hours as an intravenous (IV) infusion as a component of a multi-drug regimen. 

Recommended Dosage for Rheumatoid Arthritis: The recommended starting dosage of Methotrexate is 7.5 mg once weekly, administered intramuscularly (IM) with escalation to achieve optimal response. Dosages of 20 mg once weekly result in an increased risk of side effects, including myelosuppression. 

Recommended Dosage for Polyarticular Juvenile Idiopathic Arthritis: The recommended starting dosage of Methotrexate is 10 mg/m2 once weekly administered subcutaneously (SC) or intramuscularly (IM), with escalation to achieve optimal response.

Recommended Dosage for Psoriasis: The recommended dosage of Methotrexate is 10 mg to 25 mg intramuscularly (IM) or intravenously (IV) once weekly until adequate response is achieved.

The most common side effects of Methotrexate 50 mg/1 gm oral Injections are changes in the womb, headache, feeling lightheaded, itching of the area around the vagina, hair loss, vomiting, diarrhoea, constipation, increase in risk of blood clots, leg cramp, muscle pain, and fatty liver.

Warning and Precautions

  • Unless necessary, pregnant women should never be prescribed Methotrexate 50 mg/1 gm Injection due to its ability to cause serious fetal side effects, including death. Childbearing women need to be protected during treatment as well as for some time afterwards, as per the doctor’s guidelines.
  • Patients taking Methotrexate have reported severe allergic reactions like rash, fever, itching, and anaphylaxis. After the first few doses, patients need to be watched very carefully. Also, if any postoperative injection side effects are experienced, such as swelling, trouble breathing, or lightheadedness, then it is crucial to seek medical attention straight away.
  • Some formulations of this therapeutic drug may contain benzyl alcohol, which can be responsible for causing serious or fatal reactions in newborns or infants. Do not use it in neonates or during pregnancy unless necessary. Caution is advised in pediatric patients because of the potential toxic effects of benzyl alcohol.
  • Treatment with this medicinal product can cause suppression of bone marrow function. This may lead to anemia, low white blood cells (WBCs), and reduced platelets. Regular blood tests are important during treatment. Any signs and symptoms of infection, fatigue, easy bruising, or bleeding must be reported promptly to the treating clinician.
  • This medication can alter the ability of the immune system to fight infections. Patients should not have close contact with people who have contagious diseases. Prompt medical care is required if symptoms like fever, chills, sore throat, or cough develop during or after Methotrexate therapy.
  • Higher doses of Methotrexate can cause damage to the kidneys. Monitoring of the patient’s kidney function should be performed prior to treatment commencing and during the course of the treatment. Patients are advised to maintain adequate hydration and should be instructed to report complaints of reduced urine output, edema, or lumbar pain as these might indicate the onset of complications.
  • The long-term use of Methotrexate 50 mg/1 gm Injection may result in liver damage, such as cirrhosis, or even lead to liver failure. Patients are advised to stop consuming alcohol and be screened for liver function tests regularly. Patients need to report to their doctors any changes in their skin color to yellow, observing dark urine, or abdominal pain, as these could indicate severe underlying problems.
  • High doses or intrathecal administration of Methotrexate can have adverse effects on a patient’s nervous system. Headaches, dizziness, confusion, and seizures are some of the possible symptoms. Neurological observation is advised, and treatment should be ceased in case severe neurological complications emerge.
  • Even with low doses, lung problems such as pneumonitis or fibrosis may develop. Patients experiencing symptoms such as, but not limited to, shortness of breath, dry cough, or chest pain should report them immediately. If any respiratory symptoms develop during treatment, chest imaging along with pulmonary function tests may be needed.

FAQ's

What is Methotrexate?

Methotrexate is a generic medicine and falls under the class of medicines called folate analog metabolic inhibitors. It is commonly available in 50 mg/1 gm Injections and is primarily used for the treatment and management of certain neoplastic diseases, rheumatoid arthritis (RA), polyarticular juvenile idiopathic arthritis (pJIA), and severe psoriasis.

How is Methotrexate supplied?

Methotrexate is supplied in injection with preservative (multiple-dose vials): 50 mg/2 mL (25 mg/mL)  and preservative-free (single-dose vials): 1 g/40 mL (25 mg/mL) for intravenous (IV), intramuscular (IM), subcutaneous (SC), or intrathecal use.

How much does a Methotrexate 50 mg/1 gm Injection cost?

Please call/WhatsApp +91 8130290915 or dial our TOLL-FREE Number 1800-889-1064 to know the best Methotrexate 50 mg/1 gm injection cost in India. If you want to buy Methotrexate online, then THE INDIAN PHARMA (TIP) can help you access this oral medicinal product at the most competitive price through legal channels.

Are Methotrexate 50 mg/1 gm Injections available in India?

Methotrexate is a pharmaceutical prescription medicinal product that can only be dispensed with a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of this drug to all locations after fulfilling the legal requirements (if applicable). Please contact us at +91 8130290915 | TOLL-FREE: 1800-889-1064 or at info@theindianpharma.com to buy generic Methotrexate Injections from India at the best price.

Can I get Methotrexate 50 mg/1 gm Injections even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access Methotrexate Injections, which are not approved in their home country, against a valid prescription and in conformity with their respective country’s local laws and regulations.

Send your inquiry to find Methotrexate 50 mg/1 gm Injections prices in Mexico, Saudi Arabia, Jordan, Uzbekistan, Brazil, Chile, Colombia, Turkey, Peru, Switzerland, Venezuela, Romania, Georgia, Italy, Sri Lanka, Armenia, Germany, Azerbaijan, Tajikistan, Latvia, Poland, Kazakhstan, China, Moldova, Mongolia, Algeria, Malaysia, Mauritius, Hong Kong, Uganda, Zimbabwe, Australia, New Zealand, Cambodia, Indonesia, UAE, St. Lucia, Philippines, Turkmenistan, Singapore, Thailand, Vietnam, Slovakia, Argentina, UK, Trinidad & Tobago, Egypt, Liberia, United Arab Emirates (UAE), France, Slovak Republic, Mali, Guinea, Kenya, Fiji, Benin, Qatar, Dominican Republic, South Africa, Nepal, Ethiopia, Somalia, Cameroon, Tanzania, Congo (The Democratic Republic Of The Congo), Côte d’Ivoire, Cayman Islands, Nigeria, Zambia, Madagascar, Guatemala, Oman, Morocco, Hungary, Macedonia (The Former Yugoslav Republic Of), Namibia, United States, Jamaica, Congo, Serbia, Myanmar, Sudan, Ecuador, Malawi, Panama, Nicaragua, Belize, Greece, Bosnia & Herzegovina, Taiwan, Senegal, Burkina Faso, Papua New Guinea, Ghana, Paraguay, Bangladesh, Malta, Maldives, Niger, Sierra Leone, Lebanon, Barbados, Togo, Pakistan, St. Kitts-Nevis-Anguilla, Eritrea, Gabon, Mozambique, Grenada, El Salvador, Guyana, British Virgin Islands, Lithuania, Botswana, Haiti, Saint Vincent And The Grenadines, Netherlands, Guatemala, Angola, Laos, Kyrgyzstan, Costa Rica, Yemen, Dominica, Libya, Canada, Albania, Burundi, Kazakhstan, Belgium, Moldova (Republic Of), Laos (People’s Democratic Republic), Saint Kitts And Nevis, Saint Lucia, Seychelles, Ireland, St. Vincent, Spain, Bolivia, Rwanda, Namibia, Netherlands, Mauritania, Antilles, Suriname, Japan, Bahamas, Dominican Republic, Korea, Bulgaria, Tunisia, Portugal, Yemen, and Gambia.

Where can I buy Methotrexate 50 mg/1 gm Injections from a Trusted Supplier?

You can buy Methotrexate 50 mg/1 gm Injections online from India through a trusted generic medicine supplier, exporter, and contract manufacturer like THE INDIAN PHARMA (TIP). We are known for offering high-quality, affordable, and low-priced medicines. Contact us today for more information on availability and pricing.

Where can I get the best cost-price for Methotrexate 50 mg/1 gm Injections in India?

The price of Methotrexate 50 mg/1 gm Injections is low and reasonable in India compared to other countries. If you wish to buy Methotrexate online from India at an affordable price, contact us today. As trusted pharmaceutical wholesale distributors in India, we will help facilitate the legal supply of this therapeutic drug at the lowest possible prices.

Is it safe to buy Methotrexate 50 mg/1 gm Injections online from India?

Yes, one can buy Methotrexate 50 mg/1 gm Injections online at the best price from THE INDIAN PHARMA (TIP) if this drug is not registered or is unavailable in their country. TIP can help facilitate the supply of generic Methotrexate Injections through legal channels.

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