Darunavir

Darunavir

 

  • API:  Darunavir
  • Dosage Form: Tablets & Oral Suspension
  • Strength: 75mg/150mg/600mg/800mg & 100 mg/mL
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Description

Uses of medication:

Darunavir is a human immunodeficiency virus (HIV-1) protease inhibitor used for the treatment of HIV-1 infection in adult and pediatric patients aged 3 years and older. Darunavir must be co-administered with ritonavir and with other antiretroviral agents.

Dosage:

Darunavir tablets must be co-administered with ritonavir to exert its therapeutic effect. In absence of appropriately co-administer Darunavir with ritonavir will result in the plasma levels of darunavir that will be not sufficient to achieve the required antiviral effect and will alter a few drug interactions. Patients who have difficulty swallowing Darunavir tablets can use the 100 mg per mL Darunavir oral suspension.

The recommended dose for treatment-naïve adult patients and treatment-experienced adult patients with no darunavir resistance-associated substitutions is 800 mg (one 800 mg tablet) taken with ritonavir 100 mg once daily and with food.

The recommended dose for treatment-experienced adults with at least one darunavir resistance associated substitution is 600 mg (one 600 mg tablet) taken with ritonavir 100 mg twice daily and with food.

The recommended dosage for pregnant patients is 600 mg (one 600 mg tablet) taken with ritonavir 100 mg twice daily and with food.

Pediatric patients (aged 3 to less than 18 years and weighing at least 10 kg): a dosage of darunavir and ritonavir is based on body weight and should not exceed the adult dose. Darunavir is taken with food.

Treatment Reactions:

The most commonly reported side effects due to Darunavir/Ritonavir include:

  • diarrhea
  • nausea
  • rash
  • headache
  • vomiting
  • abdominal pain

More Info

Warnings and Precautions:

  • Darunavir in combination with ritonavir is not recommended for use in patients with severe hepatic impairment.
  • Conduct appropriate laboratory testing prior to initiating therapy with Darunavir/ritonavir and monitor patients throughout the treatment.
  • Increased AST/ALT monitoring needs to be considered in patients with underlying chronic hepatitis, cirrhosis, or in patients who have pre-treatment elevations of transaminases, mainly during the initial several months of treatment with Darunavir/ritonavir.
  • Tablets of darunavir 800 mg or any other dosage strength contain a sulfonamide moiety. This medicine should be used with caution in patients with a known sulfonamide allergy. In clinical studies with the combination of darunavir and ritonavir, the incidence and severity of rash were identical in subjects with or without a history of sulfonamide allergy.
  • Skin reactions ranging from mild to severe, including toxic epidermal necrolysis, Stevens-Johnson Syndrome, drug rash with eosinophilia and systemic symptoms, and acute generalized exanthematous pustulosis, have been observed. Discontinue therapy in case a severe reaction develops.
  • Use of darunavir/ritonavir is not recommended in pediatric patients aged below 3 years in view of toxicity and mortality observed in juvenile rats dosed with darunavir up to days 23-26 of age.
  • Women infected with human immunodeficiency virus should be instructed not to breastfeed while on treatment with darunavir/ritonavir due to the potential for HIV transmission.

Storage:

Store darunavir tablets and oral suspension at room temperature, 77°F (25°C). at 25°C (77°F); with excursions permitted to 15°C-30°C (59°F-86°F). Keep oral suspension away from the high heat.

Availability in India:

The Indian Pharma helps connect buyers with suppliers who can ship Darunavir (DRV) at the global level as per the needs of buyer’s. The Indian Pharma provides guarantee of quality and delivery for the Darunavir Tablets.

Buying Procedure:

In order to buy darunavir 600 mg or 800 mg or 150 mg or 75 mg tablets, you can contact us at our Toll-free Number 1800 889 1064 or on WhatsApp Number +91 8130290915 or an Email to us at: info@theindianpharma.com along with your Proof of Identity, Authorized Prescription Letter and Medical Reports.

Conclusion:

Darunavir, a recently approved HIV protease inhibitor (PI). It offers clinicians a promising option to treat treatment-naïve and -experienced patients. It has a favorable profile of side effects. It is well tolerated, and has demonstrated excellent potential to suppress HIV viral load and engender CD4 cell recovery. Importantly, resistance to darunavir is uncommon, facilitating the prolonged efficacy in patients.

FAQ

What does Darunavir treat?

Darunavir is used with a pharmacokinetic booster such as ritonavir to treat human immunodeficiency virus (HIV) infection in adults and children aged 3 years and older.

Is Darunavir a sulfa medicine?

Yes, Darunavir is a sulfa-containing medicine and should be used with caution by individuals with a known sulfa allergy.

How much does Darunavir cost?

Darunavir cost in India is reasonable and can vary. In order to procure it authentically, you can get in touch with us either via TOLL-FREE: 1800 889 1064 or WhatsApp: +91 8130290915 or Email: info@theindianpharma.com.

Where can I get Darunavir at the best price?

In order to get the best darunavir price, always buy this medication from a Pharmaceutical Wholesaler Company which is certified by higher authorities like WHO-GDP & ISO 9001:2008.

Can I get Darunavir even if I am not based in India?

The Indian Pharma helps patients in accessing or importing Darunavir, not approved in their home country against the legitimate prescription and in conformity with all local laws and regulations of their home country.

What is the procedure to buy Darunavir in Burundi from The Indian Pharma?

Patients can simply fill out the order form or can send mail at info@theindianpharma.com. Patients can also dial our TOLL-FREE: 1800 889 1064. We will get back to you ASAP with the details of Pricing as well as the Procedure. Note:- The order will be confirmed only after the receipt of authorized prescription of the Clinician.

Is it safe to buy Darunavir online in India?

Yes, You can buy darunavir in India online authentically from https://theindianpharma.com/ if this product is not available or has not been approved in your home country.

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