Mantle Cell Lymphoma (MCL) is a type of non-Hodgkin lymphoma, which is a cancer that begins in the cells of the immune system. Lymphomas affect lymphocytes, a kind of white blood cell (WBC). These are essential for the body’s defense against infections. MCL originates from B-cells, a type of lymphocyte located in an area of the lymph node called the “mantle zone.”
Causes and Risk Factors: The exact cause of MCL is not known, but certain factors increase the risk, such as:
- Age: Most people diagnosed with MCL are in their 60s.
- Gender: MCL is more common in men.
- Genetic Mutations: Certain chromosomal changes, such as the t(11;14) translocation, are often seen in MCL.
Sings and Symptoms: Symptoms of Mantle Cell Lymphoma (MCL) can be vague and often mimic other illnesses. They may include:
- Swollen Lymph Nodes: Painless lumps under the skin in areas like the neck, armpit, or groin.
- Fever: Unexplained and persistent.
- Night Sweats: Heavy sweating during sleep.
- Weight Loss: Sudden weight loss.
- Fatigue: Feeling very tired without a clear reason.
- Abdominal Pain: Or discomfort due to an enlarged spleen or liver.
Treatment of Mantle Cell Lymphoma with Acalabrutinib:
Acalabrutinib is a second-generation Bruton’s tyrosine kinase (BTK) inhibitor. It is supplied generically under the brand Acabrunat (Natco Pharma). This therapeutic drug is available in the dosage form of capsules for oral use. Acalabrutinib is specifically used for the treatment of mantle cell lymphoma (MCL), especially in patients who have already received other treatments but have not had success.
How Acalabrutinib Works: Acalabrutinib generic is a type of drug known as a Bruton’s Tyrosine Kinase (BTK) inhibitor. BTK is a protein in B-cells that helps them grow and survive. By blocking BTK, this therapeutic drug prevents the cancerous B-cells from multiplying and spreading, which can slow down or stop the progression of MCL.
Benefits of Acalabrutinib:
- Targeted Action: Acalabrutinib specifically targets the BTK protein, making it effective in treating MCL.
- Fewer Side Effects: Compared to traditional chemotherapy, Acalabrutinib generally has fewer and less severe side effects.
- Oral Administration: It is taken by mouth, which is more convenient than treatments that require intravenous administration.
Possible Side Effects: While treatment with Acalabrutinib capsules is effective, it can have side effects. The most commonly reported side effects include:
- Headache
- Fatigue
- Diarrhea
- Muscle Pain
- Bruising or Bleeding Easily
- Infections: Acalabrutinib can lower the body’s ability to fight infections.
Patients should be monitored for these side effects and report any unusual symptoms to their healthcare provider.
Accessing Generic Acalabrutinib from India:
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Reference: https://www.calquence.com/