The Noradrenaline injection is used for the restoration as well as maintenance of the blood pressure in all acute hypotensive or shock states which may result from surgery, trauma, hemorrhage, myocardial infarction, sympathectomy, spinal anesthesia, septicemia, drug reactions, poliomyelitis and blood transfusion reactions.
This drug is also effective as an adjunct in order to treat cardiac arrest and profound hypotension.
Dosage: The dose of adrenor injection depends on the condition of the patient. Your healthcare provider will determine the best dose to use. The noradrenaline injection is first diluted and then usually infused into a vein. The dose can be adjusted using a pump according to the response to the treatment, with the intention in order to establish a normal blood pressure. The initial dose is 0.4 to 0.8 milligrams per hour of Noradrenaline base.
Overdose with the noradrenaline injection may cause headache, severe hypertension, marked increase in peripheral resistance, decreased cardiac output and reflex bradycardia.
In case of overdosage, this drug should be discontinued until the condition of the patient stabilizes.
The most commonly reported side effect of norepinephrine include:
- psychotic state
- lower vigilance
- sensitivity to light
- difficulty in breathing
- fast or slow heart rate
- pain in the chest or throat
Warnings and Precautions:
- Patients with noradrenalin should be monitored for glucose and considered dosage adjustment of antidiabetic drugs.
- Patients with concomitant halogenated anesthetics should be monitored for cardiac rhythm.
- Blood pressure as well as heart rate will be checked frequently during your treatment to avoid hypertension.
- In order to reduce the risk of extravasation, infuse into a large vein, infusion site should be checked frequently for free flow, and signs of extravasation should be monitored.
- Susceptible patients should be monitored for changes to the skin of the extremities.
- The inj noradrenaline should be avoided contact with the iron salts, alkalis, or oxidizing agents.
- When discontinuing the infusion, the flow rate should be reduced gradually. Abrupt withdrawal should be avoided.
- Elderly patients with noradrenaline 4 mg are at higher risk of developing adverse reactions.