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Azacitidine Injection

Azacitidine

 

  • API:  Azacitidine
  • Dosage Form: For Injection
  • Strength: 100 mg as a lyophilized powder in a single-dose vial for reconstitution
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Description

Azacitidine Uses:

Azacitidine is a nucleoside metabolic inhibitor used to treat patients with the following FAB myelodysplastic syndrome (MDS) subtypes:
  • refractory anemia or refractory anemia (RA) with ringed sideroblasts (RARS) (if accompanied by thrombocytopenia or neutropenia requiring transfusions)
  • refractory anemia (RA) with excess blasts (RAEB)>
  • refractory anemia (RA) with excess blasts in transformation (RAEB-T)
  • chronic myelomonocytic leukemia (CMMoL)

Dosage:

The recommended starting dose for the initial treatment cycle, for all patients regardless of baseline hematology values, is Azacitidine 75 mg/m2 daily for 7 days to be given by subcutaneous injection or intravenous infusion. Premedicate patients for nausea and vomiting. Repeat cycles every four weeks. After two cycles, dosage may increase to Azacitidine 100 mg/m2 in case no beneficial effect is observed and no toxicity other than vomiting and nausea has occurred. Treat patients for a minimum of four to six cycles. Complete/partial response may require additional cycles. Treatment with Azacitidine should be continued as long as the patient continues to benefit. Monitor patients for renal toxicity and for hematologic response; delay/reduce the dosage as appropriate.

Side Effects:

The most commonly reported side effects due to Azacitidine by the subcutaneous route are:
  • nausea
  • anemia
  • vomiting
  • pyrexia
  • leukopenia
  • diarrhea
  • constipation
  • neutropenia
  • ecchymosis
  • thrombocytopenia
  • injection site erythema
most commonly reported side effects by intravenous route also included:
  • petechiae
  • rigors
  • weakness>
  • hypokalemia

Storage:

Azacitidine for injection is supplied as a lyophilized powder in 100 mg single-dose vials packaged in cartons of 1 vial. Store unreconstituted vials at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Availability in India:

The Indian Pharma helps connect buyers with suppliers who can ship AZACITIDINE at the global level as per the needs of buyer’s. The Indian Pharma provides a guarantee of quality and delivery for the AZACITIDINE Injections.

Buying Procedure:

In order to buy AZACITIDINE, you can contact us at our Toll-free Number 1800 889 1064 or on WhatsApp Number +91 8130290915 or an Email to us at: info@theindianpharma.com along with your Identity Proof, Valid Prescription Letter and Medical Reports.

Conclusions:

Azacitidine treatment results in significantly higher RR, improved QoL, reduced risk of leukemic transformation, and improved survival compared with supportive care. Azacitidine provides a new treatment option that is superior to supportive care for patients with the MDS subtypes.

Warning and Precautions

  • Azacitidine causes neutropenia, anemia and thrombocytopenia. Monitor complete blood counts frequently for response or toxicity, at a minimum, before each dosing cycle. Following the use of the recommended dosage for the first cycle, adjust dosage for subsequent cycles on behalf of nadir counts and hematologic response.
  • Use of Azacitidine is restricted in patients with advanced malignant hepatic tumors. Monitor liver chemistries before initiation of therapy and with each cycle. Safety and effectiveness of this medicine in patients with MDS and hepatic impairment have not been assessed as these patients were not included in the clinical trials.
  • Monitor electrolytes serum creatinine before the initiation of therapy and with each cycle. In case unexplained reductions in serum bicarbonate <20 mEq/L or elevations of BUN or serum creatinine observe, reduce or hold the azacitidine dose.
  • Patients with renal impairment may be at greater risk for renal toxicity. Also, azacitidine 100 mg and its metabolites are primarily excreted by the kidney. Therefore, evaluate these patients precisely for toxicity. Patients with MDS and renal impairment were not included in the clinical studies.
  • The azacitidine injection may be responsible for causing fatal or serious tumor lysis syndrome, including in patients with MDS. Tumor lysis syndrome may emerge despite concomitant use of allopurinol. Evaluate baseline risk and monitor and treat patients as appropriate.
  • Azacitidine can cause fetal harm if administered to a pregnant woman. Advise females with reproductive age/potential to avoid pregnancy during treatment with this medicinal product. Men should be advised to not father a child while receiving treatment with Azacitidine.

FAQ

Is azacitidine a chemotherapy medicine?

Azacitidine is a cytotoxic chemotherapy medicine. It is classified as an antimetabolite and a demethylating agent.

Can azacitidine be given IV?

Azacitidine comes as a powder to be mixed with water and injected subcutaneously or intravenously by a health specialist in a medical office or hospital outpatient department. It is usually injected once daily for 7 days.

How much does Azacitidine cost?

The azacitidine cost in India is reasonable and can vary. In order to procure it authentically, you can get in touch with us either via TOLL-FREE Number: 1800 889 1064 or Call/Whatsapp: +91 8130290915, or Email: info@theindianpharma.com.

Where can I get Azacitidine at the best price?

In order to get the best azacitidine price, you can connect with The Indian Pharma, or any other Pharmaceutical Wholesaler Company which is certified by the higher authorities like WHO-GDP & ISO 9001:2008. A valid prescription is required while buying Azacitidine.

Can I get Azacitidine even if I am not based in India?

The Indian Pharma helps patients in accessing or importing Azacitidine, not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country. Send your inquiry to find Azacitidine injection price in Ukraine, Saudi Arabia, Jordan, Mexico, Uzbekistan, Brazil, Chile, Colombia, Peru, Venezuela, Romania, Switzerland, Georgia, Turkey, Italy, Sri Lanka, Afghanistan, Germany, Azerbaijan, Latvia, Poland, Armenia, Kazakhstan, Moldova, Tajikistan, Mongolia, Algeria, Mauritius, Uganda, Zimbabwe, Australia, New Zealand, China, Cambodia, Indonesia, Malaysia, Philippines, Singapore, Thailand, Vietnam, Hong Kong, UAE, Iran, Argentina, UK, Slovakia, Turkmenistan, Trinidad & Tobago, Liberia, France, Slovak Republic, Egypt, Guinea, Kenya, Benin, Dominican Republic, Nepal, Ethiopia, Somalia, United Arab Emirates, Cameroon, St. Lucia, Mali, Tanzania, Congo (The Democratic Republic Of The Congo), Côte d’Ivoire, Cayman Islands, Nigeria, Zambia, Qatar, Madagascar, Guatemala, Oman, Morocco, Hungary, Macedonia (The Former Yugoslav Republic Of), Namibia, United States, Jamaica, Congo, Serbia, Myanmar, South Africa, Sudan, Ecuador, Fiji, Malawi, Panama, Nicaragua, Belize, Greece, Bosnia & Herzegovina, Taiwan, Senegal, Burkina Faso, Papua New Guinea, Ghana, Paraguay, Bangladesh, Malta, Maldives, Niger, Sierra Leone, Lebanon, Barbados, Togo, Pakistan, St. Kitts-Nevis-Anguilla, Eritrea, Gabon, Mozambique, Grenada, El Salvador, Russia, Guyana, British Virgin Islands, Lithuania, Botswana, Haiti, Saint Vincent And The Grenadines, Netherlands, Guatemala, Angola, Laos, Kyrgyzstan, Yemen, Dominica, Canada, Burundi, Kazakhstan, Belgium, Moldova (Republic Of), Laos (People’s Democratic Republic), Saint Kitts And Nevis, Saint Lucia, Seychelles, Rwanda, Libya, Ireland, St. Vincent, Spain, Bolivia, Netherlands Antilles, Suriname, Japan, Namibia, Albania, Mauritania, Bahamas, Dominican Republic, Bulgaria, Portugal, Yemen, Korea, Costa Rica, Tunisia, and Gambia.

Is it safe to buy Azacitidine online from India?

Yes, You can buy azacitidine from India authentically from https://theindianpharma.com/ if the product has not been approved or is not available in your home country.

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