Padcev (Enfortumab Vedotin)

  • Medicine Name: Padcev
  • API: Enfortumab Vedotin-ejfv
  • Dosage Form & Strength: For Injection: 20 mg and 30 mg of enfortumab vedotin-ejfv as a lyophilized powder in a single-dose vial for reconstitution
  • Manufacturer Name: Astellas Pharma US, Inc.
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Description

Padcev (enfortumab vedotin-ejfv) is a targeted therapy that combines a Nectin-4-directed antibody with a microtubule inhibitor. It is prescribed
  • in combination with pembrolizumab to treat adults with locally advanced or metastatic urothelial cancer.
  • as a single agent for the treatment of adults with locally advanced or metastatic urothelial cancer. This includes patients who have previously been treated with a PD-1 or PD-L1 inhibitor and platinum-based chemotherapy or those who cannot receive cisplatin-based chemotherapy and have undergone one or more prior lines of therapy.
Posology & Administration: In combination with pembrolizumab, Padcev is typically administered intravenously over 30 minutes on Days 1 and 8 of a 21-day cycle. The recommended dose is 1.25 mg/kg, with a maximum of 125 mg for patients weighing 100 kg or more. Treatment continues until disease progression or unacceptable side effects occur. For Padcev used alone, the recommended dosage is 1.25 mg/kg (up to a maximum of 125 mg for patients weighing 100 kg or more). It is given intravenously over 30 minutes on Days 1, 8, and 15 of a 28-day cycle until either disease progression or unacceptable side effects occur.

Important Safety Information

Peripheral Neuropathy: Padcev injection can cause peripheral neuropathy, which may manifest as sensory or motor neuropathy. Patients should be monitored for symptoms such as numbness, tingling, or weakness in the extremities, and dose adjustments may be necessary if neuropathy occurs. Hyperglycemia: Treatment with this medicine may lead to hyperglycemia. Blood glucose levels should be monitored regularly during treatment, and appropriate management strategies, such as antidiabetic medications or insulin, should be initiated as needed. Ocular Disorders: this treatment may cause ocular disorders, including keratitis, which can lead to vision loss or blindness. Patients should report any changes in vision or eye discomfort to their healthcare provider promptly. Skin Reactions: Dermatologic reactions, such as rash or pruritus, may occur with this therapeutic drug. Patients should be monitored for skin changes, and supportive care measures should be initiated as necessary. Infusion-Related Reactions: Infusion-related reactions, including fever, chills, or hypotension, may occur during or after Padcev 20 mg or 30 mg administration. Patients should be closely monitored during infusion, and appropriate supportive care should be provided. Embryo-Fetal Toxicity: This medicine can cause fetal harm when administered to pregnant women. Pregnancy should be avoided during treatment, and effective contraception should be used in women of childbearing potential Interstitial Lung Disease (ILD): ILD, including pneumonitis, can occur with Padcev treatment. Patients should be monitored for respiratory symptoms, and treatment should be discontinued if ILD is suspected. Hepatotoxicity: This drug may cause hepatotoxicity, characterized by elevated liver enzymes. Liver function tests should be performed regularly during treatment, and dose modifications may be necessary to manage hepatotoxicity.

Documentation & Availability

What documents are required to import PADCEV to India? PADCEV (Enfortumab Vedotin-ejfv) injections can be imported by patients or government hospitals on the name of the patients only. The following documentation is needed to import the product:
  • A valid prescription from a qualified doctor.
  • Patients diagnostic reports
  • Patient ID proof (issued by the government of India)
How does the order be confirmed? The order will be confirmed only after the receipt of:
  • Valid prescription of Doctor
  • Import permit if applicable
Is PADCEV available in India? PADCEV (Enfortumab Vedotin injection) is a (prescription drug, prescription medication, or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed. IPN (Indian Pharma Network) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input
  • On availability of Padcev in India ( Kolkata, Hyderabad, Mumbai, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
  • Medicine Price.
  • Finding Authentic and reliable sources from USA, Canada, Europe, and Australia
  • Ensuring 100% transparency.
PADCEV can be made available to patients, doctors, and hospitals in Mumbai, Goa, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit. TIP (The Indian Pharma) can facilitate the supply of PADCEV (prescription medicines) to all locations in the world and India after fulfilling the legal requirement (if applicable). Please contact +91-9310090915 | Toll-Free No: 1800-889-1064 or write us at info@theindianpharma.com for Padcev price in India. We guarantee quality and delivery in every corner of the world as per the buyer’s requirements.

Sourcing & Delivery

The Indian Pharma (TIP) can source PADCEV (Cancer Treatment Medicines) from across the globe and can supply. TIP offers its customers worldwide access to the best available treatment. The Indian Pharma (TIP) has the potential to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.

FAQs

What does Padcev contain as an active substance? Padcev specifically contains the active substance Enfortumab Vedotin-ejfv. How is Padcev supplied? Padcev is supplied for injection: 20 mg and 30 mg of enfortumab vedotin-ejfv as a lyophilized powder in a single-dose vial for reconstitution for intravenous use. What are the common side effects of Padcev? Common side effects of Padcev may include fatigue, peripheral neuropathy, decreased appetite, rash, alopecia, nausea, dysgeusia, diarrhea, dry eye, and dry skin. How much does Padcev cost in India? Get the best Padcev cost in India. If you want to buy it online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price in India through legal channels. How to store Padcev? Store vials of Padcev in a refrigerated at 2 to 8°C (36 to 46°F) in the original carton. Do not freeze. Do not shake. Is the Padcev Injection Available In India? Padcev is an imported medicine that is not readily available in India. It can be imported against a valid prescription and import permit. THE INDIAN PHARMA (TIP) can facilitate the supply of Padcev injection after fulfilling the legal requirement (if applicable). Please contact us via +919310090915 or TOLL-FREE: 1800-889-1064 or write to us at info@theindianpharma.com to buy Padcev online in India. Can I get Padcev even if I am not based in India? THE INDIAN PHARMA (TIP) helps patients access/import Padcev (Enfortumab Vedotin-ejfv), not approved in their home country against the valid prescription and in conformity with the local laws and regulations of their respective country. Where can I get Padcev at the best price? To get the best Padcev price in India and other countries, always buy this therapeutic drug from a Pharmaceutical Wholesaler Company that is GDP-certified. Noida-based THE INDIAN PHARMA (TIP) can offer the best price for Padcev (Enfortumab Vedotin-ejfv). Is it safe to buy Padcev online in India? Yes, one can buy Padcev online from India-based The Indian Pharma (TIP) if the medicine is not registered or is unavailable in the country. We can facilitate the supply of Padcev injection through legal channels.
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