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Cytarabine injection

Cytarabine

 

  • API: Cytarabine
  • Packaging & Strength: Injection: 100 mg, 500 mg & 1000 mg
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Description

Cytarabine Injection USP – 100 mg / 500 mg / 1000 mg

Antimetabolite and an antineoplastic agent.

Overview:

Cytarabine (also known as Ara-C) is a potent antineoplastic agent belonging to the antimetabolite class of chemotherapy drugs. It works by inhibiting DNA synthesis, effectively interfering with the growth and multiplication of cancer cells. Supplied in sterile injectable form, it is available in 100 mg, 500 mg, and 1000 mg strengths to accommodate individualized dosing regimens.

Cytarabine is a cornerstone in the treatment of hematological malignancies. The Indian Pharma serves as a trusted supplier, exporter, and contract manufacturer, offering both generic and brand-name options to meet global demand.

Therapeutic Indications:

Cytarabine is indicated for the management and treatment of:

  • Acute Myeloid Leukemia (AML) – First-line chemotherapy agent.
  • Chronic Myelogenous Leukemia (CML) – Used in combination protocols.
  • Meningeal Leukemia – For intrathecal administration to treat or prevent leukemic involvement of the central nervous system (CNS).

Bulk & Institutional Supply:

The Indian Pharma specializes in high-volume, compliance-driven supply for:

  • Hospitals & Cancer Centers
  • Healthcare Professionals (HCPs)
  • Government Tenders & NGOs
  • Distributors & Wholesalers

Supply Capabilities:

  • Contract Manufacturing: Custom formulations and private labeling available.
  • Export Documentation: Complete documentation support for CoA (Certificate of Analysis), Certificate of Pharmaceutical Product (CoPP), Free Sale Certificate (FSC), and GMP (Good Manufacturing Practices) certifications.
  • Packaging: Available in vials (single-dose and multi-dose) with tamper-evident seals.

Logistics & Shipping:

  • Temperature-Controlled Shipping: 2°C to 8°C cold chain management to ensure integrity during transit.
  • Global Reach: Expedited shipping to North America, Europe, MENA, Africa, Latin America, and Asia-Pacific via air freight.
  • Customs Compliance: Full support in customs clearance.

For Healthcare Professionals (HCPs):

Cytarabine is frequently administered as a continuous infusion or intrathecally. It is often used in combination with other chemotherapeutic agents (e.g., daunorubicin or idarubicin) to enhance efficacy in AML protocols.

Pharmacodynamics:

  • Mechanism of Action: Cytarabine is converted into cytarabine triphosphate, which competes with deoxycytidine triphosphate for incorporation into DNA, leading to chain termination and cell death (specifically during the S-phase of the cell cycle).

Important Safety Information:

  • Contraindications: Hypersensitivity to Cytarabine or any excipients.
  • Monitoring: Requires close monitoring for myelosuppression (neutropenia, thrombocytopenia), hepatic dysfunction, and hyperuricemia.
  • Drug Interactions: Use with caution in patients on other nephrotoxic or hepatotoxic agents. Dose adjustments are required for patients with renal impairment or those undergoing dialysis.

Clinical Statistics:

  • Efficacy in AML: High-dose Cytarabine (HiDAC) consolidation therapy has been shown to improve 5-year disease-free survival by 15–20% in adult patients under 60 years of age compared to standard-dose regimens (Source: Journal of Clinical Oncology).
  • Global Demand: The global injectable chemotherapy market is projected to grow at a CAGR of 8.5% from 2024 to 2030, with Cytarabine remaining one of the top 20 generic oncology drugs by volume.
  • Quality Assurance: In WHO prequalified facilities, sterility assurance levels (SAL) exceed 99.99% for lyophilized injectables, ensuring patient safety.

Patient Information & Support

Important: This information is for educational purposes. Always consult your oncologist or healthcare provider.

How Cytarabine Works:

Cytarabine is a chemotherapy drug that interferes with the growth of cancer cells, slowing their spread in the body. It is often given alone or combined with other chemotherapy medicines to improve treatment outcomes.

Precautions:

  • Do not take if you are allergic to Cytarabine or any of its ingredients.
  • Inform your doctor if you have:
    • Liver problems or bone marrow suppression.
    • Kidney disease (effects on patients with kidney failure require careful dose adjustment).
    • Recent or current radiation therapy.
  • Uric Acid Monitoring: Cytarabine may increase uric acid levels. Your doctor may prescribe allopurinol or hydration therapy to prevent kidney complications.

Side Effects & Management:

Like many chemotherapy drugs, Cytarabine may cause side effects. Medical supervision is essential to manage these safely.

  • Common Side Effects: Nausea, vomiting, diarrhea, fever, and temporary hair loss.
  • Serious Side Effects (Require Immediate Medical Attention):
    • Allergic Reaction: Skin rash, itching, swelling of the face/throat, wheezing, or difficulty breathing.
    • Neurotoxicity: Difficulty with coordination or balance.
    • Myelosuppression: Increased risk of infection, easy bruising, or unusual bleeding.

Follow-Up:

Regular blood tests (CBC, liver function tests, and uric acid levels) are required to monitor your body’s response. Attend all scheduled check-ups to manage side effects and ensure the best possible outcome.

Why Choose The Indian Pharma?

Feature Benefit
Regulatory Compliance WHO-GMP, PIC/S, EU-GMP certified manufacturing partners.
Supply Chain Reliability 98.5% on-time delivery rate for international shipments.
Cost Efficiency Competitive pricing for both generic and branded cytarabine.
Technical Support Dedicated team for regulatory documentation and cold chain logistics.
         

Ordering Information

The Indian Pharma is a leading Cytarabine Supplier, Exporter, and Contract Manufacturer in India.

  • Product: Cytarabine Injection USP
  • Strengths: 100 mg / 500 mg / 1000 mg vials
  • MOQ (Minimum Order Quantity): Flexible for B2B (institutional) and retail (patient) requirements.
  • Shipping: Worldwide delivery with real-time tracking.

Contact us today for a quote, bulk supply, or to discuss a contract manufacturing partnership.

Dosage & Side Effects

The recommended dose of Cytarabine is given in hospitals by trained healthcare professionals (HCPs). It is used for the treatment of certain types of blood cancers, including leukemia. This drug is administered through different methods, such as under the skin (SC), into a vein (IV), into a muscle (intramuscular), or the spine (intrathecal). The HCP decides the dose, method of administration, and duration of treatment based on the patient’s condition and medical needs. Since Cytarabine 100 mg/500 mg/1000 mg is a strong chemotherapy drug, it is only given under strict medical supervision to ensure safety. Patients receiving this injection may require regular health check-ups to monitor their progress and manage any potential side effects. It is important to follow all medical advice during treatment to achieve the best results. Always discuss any concerns with your doctor before starting or continuing the treatment with Cytarabine. The most common side effects of Cytarabine 100 mg/500 mg/1000 mg injection include anemia, fatigue, bruising, bleeding, infection, low white blood cell count, blood clots, diarrhea, loss of appetite, fever, nausea, vomiting, rash, abdominal pain, and sores in the mouth, throat, and gastrointestinal tract, including the rectum.

Warning and Precautions

  • Cytarabine can suppress the bone marrow. For patients with pre-existing medical conditions involving bone marrow suppression, careful monitoring is required. During the entire course of the treatment, blood samples are to be taken daily to measure the levels of leukocytes and platelets to catch any arising complications early enough.
  • Patients receiving treatment with Cytarabine must be under close medical supervision at all times. There should be routine examinations of bone marrow conducted frequently after blasts have been cleared from the blood. Monitoring allows for prompt management of adverse conditions such as infections and hemorrhages.
  • Participants should have access to facilities capable of treating life-threatening complications arising from granulocytopenia, thrombocytopenic infections, and hemorrhage. Proper supportive care should be provided swiftly because these conditions could prove fatal without immediate attention.
  • Anaphylactic reactions have been noted post the intravenous administration of Cytarabine such as acute cardiopulmonary arrest needing emergency resuscitation. After such drugs are administered to patients, their vital signs should be monitored closely for any signs indicative of anaphylaxis.
  • Rare cases of severe skin rashes with peeling and redness have been reported with Cytarabine treatment. Patients should be closely monitored for any skin reactions, and treatment should be reassessed if serious dermatological conditions occur to prevent further complications.
  • Total hair loss (alopecia) is more common with high-dose Cytarabine therapy than with standard treatment. Patients should be counseled beforehand about the possibility of losing all hair, as this may cause emotional distress during cancer treatment. Hair regrowth occurs after therapy.
  • Never administer this therapeutic drug with any formulation containing benzyl alcohol. This precaution is especially important in experimental treatments, as benzyl alcohol may increase toxicity risks, leading to potentially serious side effects and unexpected health complications.
  • This therapeutic drug is teratogenic and may cause severe birth defects if used during pregnancy. Women of childbearing potential should use effective contraception throughout the treatment to prevent fetal harm, as exposure may lead to serious congenital abnormalities or pregnancy loss.

FAQ's

What is Cytarabine? Cytarabine is an antineoplastic drug. It is commonly available in 100 mg/500 mg/1000 mg injections and is primarily used for the treatment of patients with acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and Meningeal leukemia.  How is Cytarabine injection supplied? Cytarabine injection is supplied in 100 mg, 500 mg, and 1000 mg strengths. It is available in vials for intravenous (IV), subcutaneous (SC), or intrathecal (IT) administration, depending on medical requirements. How much does Cytarabine 100 mg/500 mg/1000 mg injection cost? Please Call/WhatsApp: +91 8130290915 or dial our TOLL-FREE Number: 1800-889-1064 to know the best Cytarabine 100 mg/500 mg/1000 mg injection cost in India. If you want to buy Cytarabine online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price through legal channels. Is Cytarabine 100 mg/500 mg/1000 mg injection available in India? Cytarabine is a pharmaceutical prescription medicinal product that can only be dispensed against a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of this drug to all locations after fulfilling the legal requirements (if applicable). Please contact us at +91 8130290915 | TOLL-FREE: 1800-889-1064 or at info@theindianpharma.com to buy generic Cytarabine 100 mg/500 mg/1000 mg injections from India at the best price. Can I get Cytarabine 100 mg/500 mg/1000 mg injections even if I am not based in India? THE INDIAN PHARMA (TIP) helps patients access Cytarabine 100 mg/500 mg/1000 mg injections, which are not approved in their home country, against a valid prescription and in conformity with their respective country’s local laws and regulations. Send your inquiry to find Cytarabine 100 mg/500 mg/1000 mg injection prices in Mexico, Saudi Arabia, Jordan, Uzbekistan, Brazil, Chile, Ukraine, Colombia, Turkey, Peru, Switzerland, Venezuela, Romania, Georgia, Italy, Sri Lanka, Afghanistan, Armenia, Germany, Azerbaijan, Tajikistan, Latvia, Poland, Kazakhstan, China, Moldova, Mongolia, Algeria, Malaysia, Mauritius, Hong Kong, Uganda, Zimbabwe, Australia, New Zealand, Cambodia, Indonesia, UAE, St. Lucia, Philippines, Turkmenistan, Singapore, Thailand, Iran, Vietnam, Slovakia, Argentina, UK, Trinidad & Tobago, Egypt, Liberia, United Arab Emirates (UAE), France, Slovak Republic, Mali, Guinea, Kenya, Fiji, Benin, Qatar, Dominican Republic, South Africa, Nepal, Ethiopia, Somalia, Cameroon, Tanzania, Congo (The Democratic Republic Of The Congo), Côte d’Ivoire, Cayman Islands, Nigeria, Zambia, Madagascar, Guatemala, Oman, Morocco, Hungary, Macedonia (The Former Yugoslav Republic Of), Namibia, United States, Jamaica, Congo, Serbia, Myanmar, Sudan, Ecuador, Malawi, Panama, Nicaragua, Belize, Greece, Bosnia & Herzegovina, Taiwan, Senegal, Burkina Faso, Papua New Guinea, Ghana, Paraguay, Bangladesh, Malta, Maldives, Niger, Sierra Leone, Lebanon, Barbados, Togo, Pakistan, St. Kitts-Nevis-Anguilla, Eritrea, Gabon, Mozambique, Grenada, El Salvador, Russia, Guyana, British Virgin Islands, Lithuania, Botswana, Haiti, Saint Vincent And The Grenadines, Netherlands, Guatemala, Angola, Laos, Kyrgyzstan, Costa Rica, Yemen, Dominica, Libya, Canada, Albania, Burundi, Kazakhstan, Belgium, Moldova (Republic Of), Laos (People’s Democratic Republic), Saint Kitts And Nevis, Saint Lucia, Seychelles, Ireland, St. Vincent, Spain, Bolivia, Rwanda, Namibia, Netherlands, Mauritania, Antilles, Suriname, Japan, Bahamas, Dominican Republic, Korea, Bulgaria, Tunisia, Portugal, Yemen, and Gambia. Where can I buy Cytarabine 100 mg/500 mg/1000 mg injections from a Trusted Supplier?   You can buy Cytarabine 100 mg/500 mg/1000 mg injection online from India through a trusted generic medicine supplier, exporter, and contract manufacturer like THE INDIAN PHARMA (TIP). We are known for offering high-quality, affordable, and low-priced medicines. Contact us today for more information on availability and pricing. Where can I get the best Cytarabine 100 mg/500 mg/1000 mg injection Cost Price in India?   The price of Cytarabine 100 mg/500 mg/1000 mg injection is low and reasonable in India compared to other countries. If you wish to buy Cytarabine online from India at an affordable price, contact us today. As trusted pharmaceutical wholesale distributors in India, we will help facilitate the legal supply of this therapeutic drug at the lowest possible prices. Is it safe to buy Cytarabine 100 mg/500 mg/1000 mg injections online from India? Yes, one can buy Cytarabine 100 mg/500 mg/1000 mg injections online at the best price from THE INDIAN PHARMA (TIP) if this drug is not registered or is unavailable in their country. TIP can help facilitate the supply of generic Cytarabine injections through legal channels.

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