Orkambi (Lumacaftor/Ivacaftor)

Fact of Medicine

  • Brand Name: Orkambi
  • Innovator Brand Name: Orkambi
  • API: Lumacaftor and Ivacaftor
  • Packaging: 112 Tablets
  • Strength: 200 mg/100 mg
  • Manufacturer Name: Vertex Pharma Ltd.
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Description

(ORKAMBI is registered trademarks Vertex Pharmaceuticals Incorporated)

lumacaftor-ivacaftor used for: Orkambi is a fixed-dose combination medication comprising 200 mg lumacaftor and 125 mg ivacaftor, used for the treatment of cystic fibrosis (CF) in patients aged 6-years and older.

Dosage: Always take orkambi exactly as your healthcare practitioner has told you. The recommended orkambi dosage for patients aged 6-11 years and 12-years and older is 2-tablets in the morning, and 2-tablets in the evening (12 hours apart) as the strength of Orkambi 100 mg/125 mg and Orkambi 200 mg/125 mg respectively. That is a total of 4-tablets daily, to be taken through food containing fat.

Treatment Reactions: The most commonly reported orkambi side effects may include:

  • Headache
  • Diarrhoea
  • Increase in sputum
  • Nausea
  • Common cold
  • Dizziness
  • Cough with sputum
  • Nasal congestion
  • Shortness of breath
  • Abdominal pain (stomach ache)

Warnings and precautions

  • Avoid using lumacaftor/ivacaftor, in case you are allergic to this medicine, or any of it’s existing ingredients.
  • Use of lumacaftor-ivacaftor tablet is not recommended in patients other than those who have a couple of copies of the F508del mutation in their CFTR gene.
  • Discuss with your healthcare provider prior to taking lumacaftor and ivacaftor in case you’ve been told you have liver/kidney disease as the healthcare practitioner may need to adjust the dose of orkambi.
  • Your healthcare practitioner should perform some blood tests in order to check your liver prior to and while taking the orkambi tablet, mainly during the initial year.
  • An increase in blood pressure has been observed in certain patients treated with lumacaftor/ivacaftor. Your healthcare practitioner may monitor your blood pressure while on treatment with this medication.
  • Use of orkambi is not recommended in those patients who have undergone an organ transplant.
  • Use of lumacaftor and ivacaftor tablets should be avoided in children aged under 6 years.
  • In case you’re pregnant or breast-feeding, think you may be pregnant, or want to have a baby, ask your healthcare professional for advice prior to taking this medication.

More Info.

Storage: Orkambi Tablets should be stored at room temperature between 68°F-77°F (20°C-25°C). It is not recommended to use these tablets after the expiration date printed on the package.

Availability in India: The Indian Pharma helps connect buyers with suppliers who can ship ORKAMBI at the global level as per the need of buyer’s. The Indian Pharma provides guarantee of quality and delivery for the ORKAMBI Tablets.

Buying Procedure: In order to buy ORKAMBI, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +919310090915 or an Email to us at: info@theindianpharma.com along with your Identity Proof, Valid Prescription Letter and Medical Reports.

Conclusion: Orkambi, a fixed-dose combination medication has been shown to improve lung function as well as lung ventilation in patients with CF (Cystic Fibrosis).

Commonly Asked Questions

What is ORKAMBI

ORKAMBI is a medicine that contains the active substance Lumacaftor/Ivacaftor and is available as tablets.

What does Orkambi contain as an active substance?

The Orkambi specifically contains the active substance Lumacaftor and Ivacaftor.

From which class of drug Orkambi belongs?

Orkambi belongs to a group of drugs named cystic fibrosis transmembrane conductance regulator (CFTR) modulators.

How does Lumacaftor-Ivacaftor act?

In this combination medication, Ivacaftor mainly increases the activity of the protein named CFTR, while the lumacaftor helps in order to improve protein folding of the CFTR protein.

How much does orkambi cost?

The orkambi price in india may vary depending on the pharmacy you visit. The cost for 125 mg-100 mg Orkambi oral tablet is around 1,573,128 INR for the supply of 112 tablets.

Where can I get Orkambi at the best price?

In order to get the best orkambi price, always buy this medication from a such Pharmaceutical Wholesaler Company which is ISO and WHO-GDP certified.

Can I get Orkambi even if I am not based in India?

The Indian Pharma helps patients in accessing or importing Orkambi, not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country.

In how many countries ORKAMBI is approved for marketing?

ORKAMBI is available/approved in USA and Europe. We can help you to access it in India.

What is ORKAMBI used for?

ORKAMBI is indicated for the treatment of cystic fibrosis (CF) in patients age 12 years and older who are homozygous for the F508del mutation in the CFTR gene. We facilitate by-

  •  Helping in documentation to import the medicine for personal use
  • Finding Genuine and reliable source in USA, Europe and Japan
  •  Ensuring 100% transparency.

ORKAMBI can be shipped to Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Jaipur, Lucknow, Cochin and Pune and other cities in India. The Indian Pharma can facilitate the supply of ORKAMBI (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement. The Indian Pharma does not manufacture, supply, re-sell or retail any drugs or medicines. All trademarks and other intellectual property in relation to drugs and medicines supplied to you by suppliers are owned by their respective manufacturers or licensees

Can I get ORKAMBI even if I am not based in India?

Almost all countries across the world have provisions for granting access to drugs prior to marketing approval for personal use for patients who have exhausted all other treatment options available in their country The Indian Pharma (IP) can help patients in accessing/importing ORKAMBI, unapproved in their home country against a legitimate prescription and in conformity with all local laws and regulations of their home country. Send your inquiry to find Orkambi (Lumacaftor/Ivacaftor) in UAE Iraq, Iran, Saudi Arabia, Jordan, Mexico, Argentina, Brazil, Chile, Colombia, Peru, Venezuela, Romania, Switzerland, Georgia, Turkey, Italy, UK, Ukraine, Azerbaijan, Latvia, Poland, Slovakia, Armenia, Kazakhstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan, Mongolia, Algeria, Mauritius, Uganda, Zimbabwe. Australia and New Zealand. China, Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, Vietnam, Hong Kong

Are there any side-effects/ adverse reactions/precautions associated with treatment with ORKAMBI?

It is recommended to seek your doctor’s medical advice about side effects

What information do you need to help patient in assisting documentation for ORKAMBI import for personal use? We will require the following documents to help in documentation for Named-Patient import

  • Doctor’s Prescription – We would require prescription from Registered Medical Practitioner Stating Product name, dosage, duration of treatment and diagnosis
  • Patient’s Medical history – We would require all test reports and Medical reports of the patient for last 3 months.
  • Patient’s Identity card – We will require scan copy of Patient’s identity card and proof of residence to initiate documentation process. You can use copy of Passport, Driving License, Employee ID card or any Photo ID document as your Identity card.

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