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Imatinib tablet

Imatinib 100 MG/ 400 MG Tablets

  • Medicine Name: Imatinib  
  • API: Imatinib 
  • Packaging & Strength: Tablets: 100 mg and 400 mg
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Description

Uses of Medicine:

Imatinib 100 mg/400 mg is a tyrosine kinase inhibitor (TKI). Patients, Healthcare Professionals (HCP), or Hospitals can buy Imatinib 100 mg and 400 mg Tablets online from India through THE INDIAN PHARMA (a trusted Imatinib Supplier, Exporter, and Contract Manufacturer in India) for the management and treatment of: 
  • Newly diagnosed Ph+ CML (chronic phase) in adults and children
  • Ph+ CML in blast crisis, accelerated phase, or post-interferon failure
  • Relapsed/refractory Ph+ ALL in adults
  • Newly diagnosed Ph+ ALL in children (with chemotherapy)
  • Myelodysplastic/Myeloproliferative Diseases (MDS/MPD) with PDGFR gene rearrangements in adults
  • Aggressive Systemic Mastocytosis (ASM) without D816V c-Kit mutation or unknown status
  • Hypereosinophilic syndrome/Chronic eosinophilic leukemia (HES/CEL) with or without FIP1L1-PDGFRα mutation in adults
  • Unresectable, recurrent, or metastatic dermatofibrosarcoma protuberans (DFSP) in adults
  • Unresectable/metastatic Kit-positive gastrointestinal stromal tumors (GIST)
  • Adjuvant treatment post-resection of Kit-positive gastrointestinal stromal tumors (GIST) in adults

Imatinib 100 mg/400 mg belongs to a class of cancer medications known as tyrosine kinase inhibitors. It helps adults and children suffering from chronic myeloid leukemia (CML). CML is a kind of blood cancer where certain types of white blood cells (WBCs) multiply uncontrollably. It is also indicated for patients with Ph+ acute lymphoblastic leukemia (Ph+ ALL), which is another form of aggressive blood cancer. Besides leukemia, this drug also helps manage some gastrointestinal stromal tumors (GIST). These tumors are rare in that they develop in the walls of the digestive tract and have the potential to metastasize.

Imatinib 100 mg/400 mg tablets are also widely used in the management of myelodysplastic/myeloproliferative syndromes (MDS/MPD)—a collection of disorders where blood cell production is dysregulated. This oral therapeutic drug is also effective in treating patients with hypereosinophilia syndrome (HES) and chronic eosinophilic leukaemia (CEL). These are diseases characterized by excessive production of eosinophils (a type of white blood cell) within the body. This drug is also used for a rare type of cancer, dermatofibrosarcoma protuberans (DFSP), which affects subcutaneous tissue. The medicine acts by inhibiting the progression of pathological cells.

If you’re allergic to Imatinib 100 mg/400 mg or any components of this medicine, do not take it. Also, notify your doctor if you have any issues relating to your heart, liver, or kidneys before treatment. Moreover, notify your doctor if your thyroid is castrated and if you have any kind of thyroid problems. Inform your healthcare professional if acquiring Hepatitis B is possible in your case, as this drug might trigger the disease.

Take care of all the directives from your healthcare professional (HCP). Report any cases of easy bruising, fever, excessive tiredness, abnormal bleeding, or even confusion, as these might be side effects. Additionally, this treatment may impact your fertility, so consult your doctor if this is an issue before starting the treatment.

Dosage & Side Effects:

The recommended dosage of Imatinib should be taken with a meal and a large glass of water. Doses of 400 mg or 600 mg should be administered once daily, whereas a dose of 800 mg should be administered as 400 mg twice daily. This medicine can be dissolved in water or apple juice for patients having difficulty swallowing. Daily dosing of 800 mg or more needs to be accomplished through the 400-mg tablet to reduce exposure to iron.
  • Adults with Ph+ CML CP: 400 mg/day 
  • Adults with Ph+ CML AP or BC: 600 mg/day
  • Pediatrics with Ph+ CML CP: 340 mg/m2 /day
  • Adults with Ph+ ALL: 600 mg/day
  • Pediatrics with Ph+ ALL: 340 mg/m2 /day
  • Adults with MDS/MPD: 400 mg/day
  • Adults with ASM: 100 mg/day or 400 mg/day
  • Adults with HES/CEL: 100 mg/day or 400 mg/day
  • Adults with DFSP: 800 mg/day
  • Adults with metastatic and/or unresectable GIST: 400 mg/day
  • Adjuvant treatment of adults with GIST: 400 mg/day
  • Patients with mild to moderate hepatic impairment: 400 mg/day
  • Patients with severe hepatic impairment: 300 mg/day

The most common side effects of Imatinib 100 mg and 400 mg oral tablets are fatigue, edema, diarrhea, musculoskeletal pain, nausea, vomiting, rash, muscle cramps, and abdominal pain.

Warning and Precautions

  • Treatment with Imatinib 100 mg/400 mg tablets may be responsible for causing fluid buildup in the body. This can lead to swelling in the hands, legs, or around the eyes. Severe cases may result in fluid around the lungs or heart. Regular monitoring and dose adjustments are advised to manage symptoms.
  • Patients may also experience decreased blood cell counts, including leukocytes, erythrocytes, and thrombocytes, which may result in weakness, higher chances of infections, or even bleeding. Blood tests are essential, and treatment needs to be tailored to these effects, so frequent testing is crucial.
  • Some heart-associated symptoms, such as Congestive heart failure or reduction in ventricular pumping force, have been noted on Imatinib. Existing heart conditions require close monitoring for symptoms like weight gain, increased shortness of breath, and peripheral swelling. These symptoms must be closely observed during the early treatment phase.
  • Liver damage was shown to increase with Imatinib use. The possible signs include icterus of the skin and mucosa, brownish urine, or pain in the abdomen. The liver must be monitored, and activation of therapy needs to be reconsidered because of the massive increase in enzymes secreted by the liver during its functions.
  • Cases of severe bleeding have also been documented, particularly in individuals with malignancies. Symptoms may include blood being present in stool, vomit, and urine, or even atypical bruising. Monitoring for bleeding or signs of bleeding is crucial and may necessitate changes to treatment dosing.
  • As with many medications, Imatinib may bring forth side effects such as nausea, vomiting, diarrhea, and abdominal pain or discomfort. For the majority of patients, these side effects are not severe, though some may require medical attention. Hydration, light diet, suppression of symptoms, and reporting to a healthcare specialist for serious or persistent symptoms are critical for patient recovery.
  • In extreme cases, hypereosinophilic syndrome patients may develop inflammation of the heart muscle. This may result in severe heart complications such as heart failure. Monitoring heart function at the start of treatment is essential in order to recognize any early symptoms like chest pain, fatigue, or breathlessness.
  • Skin reactions, which may manifest as rashes, skin dryness, or even severe cases such as Stevens-Johnson syndrome, have been reported. Patients should take note of any changes to their skin and inform their physicians. In severe cases, clinical evaluation may necessitate treatment interruption or complete withdrawal of treatment.
  • While a patient is on Imatinib therapy, they may experience low thyroid levels even while on thyroid hormone replacement therapy. Regular and consistent thyroid function testing is recommended and needs to be done at intervals. In this scenario, patients may experience tiredness, weight gain, enhanced sensitivity to cold, or depression. The thyroid medicine dose may require adjustment during treatment.
  • There are certain rare scenarios where Imatinib can cause dangerously fast breakdown of cancer cells, leading to a dangerous imbalance in blood chemistry. This condition is more common in patients who have a high tumor burden. Some electrolyte derangements, such as hypertension and hyperkalemia, can occur as a result of this. These patients should be hydrated and monitored closely for electrolyte derangements, making the need for additional medication unnecessary.
  • Imatinib should not be used during pregnancy as it will harm an unborn and developing baby unless under ideal conditions, not medically necessary. Women who are expectant mothers or should be using effective contraception while breastfeeding should not be recommended during treatment unless clinically recommended.

FAQ's

What is Imatinib?

Imatinib is a generic medicine and falls under the class of medicines called tyrosine kinase inhibitors. It is commonly available in 100 mg and 400 mg Tablets and is primarily used for the treatment and management of Chronic myeloid leukemia (CML), Philadelphia chromosome positive acute lymphoblastic leukemia (ph-positive ALL), Myelodysplastic/myeloproliferative diseases (MDS/MPD), Hypereosinophilic syndrome (HES), Chronic eosinophilic leukemia (CEL), Dermatofibrosarcoma protuberans (DFSP), and Gastrointestinal stromal tumors (GIST).

How is Imatinib supplied?

Imatinib is supplied in the form of 100 mg and 400 mg Tablets for oral administration. This oral therapeutic drug is commonly used for the treatment of Chronic myeloid leukemia (CML), Ph+ acute lymphoblastic leukemia (ALL), Myelodysplastic/myeloproliferative diseases (MDS/MPD), and certain other conditions.

How much does an Imatinib 100 mg and 400 mg Tablet cost?

Please call/WhatsApp +91 8130290915 or dial our TOLL-FREE Number 1800-889-1064 to know the best Imatinib 100 mg/400 mg Tablets cost in India. If you want to buy Imatinib online, then THE INDIAN PHARMA (TIP) can help you access this oral medicinal product at the most competitive price through legal channels.

Are Imatinib 100 mg and 400 mg Tablets available in India?

Imatinib is a pharmaceutical prescription medicinal product that can only be dispensed with a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of this drug to all locations after fulfilling the legal requirements (if applicable). Please contact us at +91 8130290915 | TOLL-FREE: 1800-889-1064 or at info@theindianpharma.com to buy generic Imatinib Tablets from India at the best price.

Can I get Imatinib 100 mg and 400 mg Tablets even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access Imatinib Tablets, which are not approved in their home country, against a valid prescription and in conformity with their respective country’s local laws and regulations.

Send your inquiry to find Imatinib 100 mg/400 mg Tablets prices in Mexico, Saudi Arabia, Jordan, Uzbekistan, Brazil, Chile, Colombia, Turkey, Peru, Switzerland, Romania, Georgia, Italy, Sri Lanka, Armenia, Germany, Azerbaijan, Tajikistan, Latvia, Poland, Kazakhstan, China, Moldova, Mongolia, Algeria, Malaysia, Mauritius, Hong Kong, Uganda, Zimbabwe, Australia, New Zealand, Cambodia, Indonesia, UAE, St. Lucia, Philippines, Turkmenistan, Singapore, Thailand,Vietnam, Slovakia, Argentina, UK, Trinidad & Tobago, Egypt, Liberia, United Arab Emirates (UAE), France, Slovak Republic, Mali, Guinea, Kenya, Fiji, Benin, Qatar, Dominican Republic, South Africa, Nepal, Ethiopia, Somalia, Cameroon, Tanzania, Congo (The Democratic Republic Of The Congo), Côte d’Ivoire, Cayman Islands, Nigeria, Zambia, Madagascar, Guatemala, Oman, Morocco, Hungary, Macedonia (The Former Yugoslav Republic Of), Namibia, United States, Jamaica, Congo, Serbia, Myanmar, Sudan, Ecuador, Malawi, Panama, Nicaragua, Belize, Greece, Bosnia & Herzegovina, Taiwan, Senegal, Burkina Faso, Papua New Guinea, Ghana, Paraguay, Bangladesh, Malta, Maldives, Niger, Sierra Leone, Lebanon, Barbados, Togo, St. Kitts-Nevis-Anguilla, Eritrea, Gabon, Mozambique, Grenada, El Salvador, Guyana, British Virgin Islands, Lithuania, Botswana, Haiti, Saint Vincent And The Grenadines, Netherlands, Guatemala, Angola, Laos, Kyrgyzstan, Costa Rica, Yemen, Dominica, Libya, Canada, Albania, Burundi, Kazakhstan, Belgium, Moldova (Republic Of), Laos (People’s Democratic Republic), Saint Kitts And Nevis, Saint Lucia, Seychelles, Ireland, St. Vincent, Spain, Bolivia, Rwanda, Namibia, Netherlands, Mauritania, Antilles, Suriname, Japan, Bahamas, Dominican Republic, south Korea, Bulgaria, Tunisia, Portugal, Yemen, and Gambia.

Where can I buy Imatinib 100 mg and 400 mg Tablets from a Trusted Supplier?

You can buy Imatinib 100 mg/400 mg Tablets online from India through a trusted generic medicine supplier, exporter, and contract manufacturer like THE INDIAN PHARMA (TIP). We are known for offering high-quality, affordable, and low-priced medicines. Contact us today for more information on availability and pricing.

Where can I get the best cost-price for Imatinib 100 mg and 400 mg Tablets in India?

The price of Imatinib 100 mg/400 mg Tablets is low and reasonable in India compared to other countries. If you wish to buy Imatinib online from India at an affordable price, contact us today. As trusted pharmaceutical wholesale distributors in India, we will help facilitate the legal supply of this therapeutic drug at the lowest possible prices.

Is it safe to buy Imatinib 100 mg and 400 mg Tablets online from India?

Yes, one can buy Imatinib 100 mg/400 mg Tablets online at the best price from THE INDIAN PHARMA (TIP) if this drug is not registered or is unavailable in their country. TIP can help facilitate the supply of generic Imatinib Tablets through legal channels.

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