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Bendamustine 100 mg injection

Bendamustine

Facts of BENDAMUSTINE

  • API: Bendamustine
  • Packaging & Strength: Injection: 100 mg/4 mL (25 mg/mL) in a multiple-dose vial
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Description

Uses of Medicine:

Bendamustine 100 mg/4 mL injection is an antineoplastic drug belonging to the class of alkylating agents. It is supplied generically as well as in branded medicine. Patients, Healthcare Professionals (HCPs), or Hospitals can buy Bendamustine 100 mg injection online from India through THE INDIAN PHARMA (a trusted Bendamustine Supplier, Exporter, and Contract Manufacturer in India) for the management and treatment of adult patients with:
  • Chronic lymphocytic leukemia (CLL). 
  • Indolent B-cell non-Hodgkin lymphoma (NHL)

Bendamustine 100 mg/4 mL is used for the prevention and treatment of chronic lymphocytic leukemia (cancer of blood and bone marrow) and non-Hodgkin’s lymphomas (cancer that forms in the lymph system, part of the immune system).

Bendamustine 100 mg/4 mL Injection is often combined with Rituximab, an immunotherapy drug, to treat non-Hodgkin’s lymphoma, including follicular lymphoma and mantle cell lymphoma (MCL). This medicine helps slow down the progression of cancerous cells. It is administered under proper medical supervision. However, using Bendamustine 100 mg/4 mL may be slightly responsible for increasing the risk of non-melanoma skin cancer. It is important to consult your healthcare provider immediately if you notice any skin changes.

Before starting this treatment, your healthcare professional will check your white blood cell (leukocyte) count. If the count is too low, treatment should be delayed to avoid complications. Do not use this medicine if you are allergic to it. Men planning to become fathers should consult their doctor before starting treatment, as this injection may reduce sperm production. Your doctor will monitor your blood counts regularly to ensure safety during the treatment.

Bendamustine 100 mg/4 mL Injection is administered as an intravenous (IV) infusion over 30 to 60 minutes. The dosage is usually given once every 3 to 4 weeks, depending on the condition being treated. Before starting treatment with this medicine, let your doctor know about all the medicines, herbal products, and supplements you are taking. This will help prevent any life-threatening interactions. Always follow your doctor’s advice and do not miss any scheduled or prescribed doses for effective treatment.

Dosage & Side Effects:  Recommended Dosage for CLL:

The recommended dosage for Chronic Lymphocytic Leukemia (CLL) is 100 mg/m². It is given intravenously over 30 minutes. The dosage is administered on Days 1 and 2 of a 28-day cycle. Treatment continues for up to 6 cycles. A doctor will monitor the patient’s response. The dose may be adjusted based on side effects. It is important to follow the prescribed schedule. 

Recommended Dosage for NHL: The recommended dosage for Non-Hodgkin’s Lymphoma (NHL) is 120 mg/m². It is given intravenously over 60 minutes. The dose is administered on Days 1 and 2 of a 21-day cycle. Treatment continues for up to 8 cycles. The dosage is based on body surface area (m²). A doctor will calculate the exact amount. It is important to follow the prescribed schedule. Delays or missed doses should be discussed with a doctor.

The most common side effects of Bendamustine in CLL are anemia, thrombocytopenia, neutropenia, leukopenia, lymphopenia, hyperbilirubinemia, nausea, pyrexia, and vomiting. Side effects in NHL are cough, lymphopenia, leukopenia, anemia, neutropenia, thrombocytopenia, nausea, fatigue, vomiting, diarrhea, pyrexia, dyspnea, constipation, headache, anorexia, weight decrease, rash, and stomatitis.

Warning and Precautions

  • Bendamustine 100 mg injection treatment may result in severe myelosuppression characterized by anemia, neutropenia, and thrombocytopenia. Blood counting needs to be supervised frequently. In order to avert life-threatening infections and hemorrhagic manifestations stemming from low blood cell counts, it may be necessary to adjust dosages, pause treatment, or provide other supportive measures.
  • Patients receiving Bendamustine are at an increased risk of serious bacterial and viral fungal infections. Immunosuppressed patients may have opportunistic infections necessitating protective action. All diagnostic tests for fever or infection should be immediately followed by consideration for antibiotic or antifungal treatment as deemed appropriate.
  • Bendamustine has been associated with PML, a rare but fatal brain infection due to the JC virus. Patients with PML may present with confusion, vision loss, and motor weakness. If PML is suspected, Bendamustine should be stopped immediately, and supportive care must be provided as a priority to minimize the patient’s risk of severe neurological damage.
  • TLS stems from the rapid destruction of cancerous cells, which may cause electrolyte imbalance, kidney injury, and subsequently heart issues. A high burden of tumors may require hydration and monitoring as preventative measures. In such patients, early intervention may be required with agents lowering urine acid to prevent desert TLS.
  • Cases illustrating severe rashes have been reported, such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Patients should be observed closely for rash and blister or mucosal involvement. In the instance of serious skin reactions, Bendamustine should be withdrawn and appropriate medical treatment initiated.
  • Bendamustine has the potential to be hepatotoxic due to increased liver enzymes, possible hepatitis, and liver failure. Liver function tests have to be done before and during treatment. Extreme precaution is needed in those patients who have pre-existing liver disease, and some may need to have dose modification.
  • Chronic use of Bendamustine is associated with secondary malignancies such as myelodysplastic syndrome and acute leukemia. The patients need to be followed for any signs of new primary malignancies, and a careful assessment of therapy benefit versus its risks is mandated.
  • Bendamustine is a vesicant and will cause local tissue damage if it is allowed to extravasate. Infusion sites should be visually checked for swelling, redness and tenderness. In the case of extravasation, stop infusion and commence correct local treatment without delay.
  • When used in pregnant patients, this therapeutic agent will cause fetal harm. Women of childbearing age are advised to use efficacious contraception. If a patient that is given therapy becomes pregnant, discuss the risk to the fetus and alternative treatment options.

FAQ's

What is Bendamustine?

Bendamustine is a generic medicine. It is commonly available in 100 mg/4 mL injections and is primarily used for the treatment of Chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphomas (nHL)

How is the Bendamustine injection supplied?

Bendamustine is supplied in the form of Injection: 100 mg/4 mL (25 mg/mL) in a multiple-dose vial for intravenous use.

How much does a Bendamustine 100 mg injection cost?

Please call/WhatsApp +91 8130290915 or dial our TOLL-FREE Number 1800-889-1064 to know the best Bendamustine 100 mg injection cost in India. If you want to buy Bendamustine online, then THE INDIAN PHARMA (TIP) can help you access this medicinal product at the most competitive price through legal channels.

Is a Bendamustine 100 mg injection available in India?

Bendamustine is a pharmaceutical prescription medicinal product that can only be dispensed with a valid prescription from a treating physician. THE INDIAN PHARMA (TIP) can facilitate the supply of this drug to all locations after fulfilling the legal requirements (if applicable). Please contact us at +91 8130290915 | TOLL-FREE: 1800-889-1064 or at info@theindianpharma.com to buy generic Bendamustine 100 mg injections from India at the best price.

Can I get Bendamustine 100 mg injections even if I am not based in India?

THE INDIAN PHARMA (TIP) helps patients access Bendamustine 100 mg/4 mL injections, which are not approved in their home country, against a valid prescription and in conformity with their respective country’s local laws and regulations.

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Where can I buy Bendamustine 100 mg injections from a Trusted Supplier?

You can buy Bendamustine 100 mg injection online from India through a trusted generic medicine supplier, exporter, and contract manufacturer like THE INDIAN PHARMA (TIP). We are known for offering high-quality, affordable, and low-priced medicines. Contact us today for more information on availability and pricing.

Where can I get the best Bendamustine 100 mg injection Cost Price in India?

The price of Bendamustine 100 mg injections is low and reasonable in India compared to other countries. If you wish to buy Bendamustine online from India at an affordable price, contact us today. As trusted pharmaceutical wholesale distributors in India, we will help facilitate the legal supply of this therapeutic drug at the lowest possible prices.

Is it safe to buy Bendamustine 100 mg injections online from India?

Yes, one can buy Bendamustine 100 mg injections online at the best price from THE INDIAN PHARMA (TIP) if this drug is not registered or is unavailable in their country. TIP can help facilitate the supply of generic Bendamustine injections through legal channels.

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