Retevmo (Selpercatanib) is a game-changing medication in the world of oncology, offering targeted therapy for patients with specific genetic alterations in various cancers.
Indications and Usage
Retevmo is a kinase inhibitor used for the treatment of several cancer types:
1. Non-Small Cell Lung Cancer (NSCLC): It is prescribed for adults with locally advanced or metastatic NSCLC harboring a RET gene fusion, as detected by an FDA-approved test.
2. Medullary Thyroid Cancer (MTC): It’s a systemic therapy option for adults and pediatric patients aged 12 and older with advanced or metastatic MTC carrying a RET mutation.
3. Thyroid Cancer with RET Gene Fusion: For adult and pediatric patients aged 12 and older with advanced or metastatic thyroid cancer having a RET gene fusion, as detected by an FDA-approved test, and being radioactive iodine-refractory.
4. Solid Tumors with RET Gene Fusion: Retevmo may be used in patients with RET gene fusion-positive solid tumors that have progressed on prior systemic treatment or have no satisfactory alternatives.
Dosage and Administration
The dosage depends on the patient’s weight:
1. For adults and pediatric patients aged 12 or older weighing less than 50 kg, the recommended dosage is 120 mg orally twice daily.
2. For those weighing 50 kg or more, the recommended dosage is 160 mg orally twice daily.
Patients with severe hepatic impairment require a reduced dose.
Retevmo Side Effects
Common adverse reactions include edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, and headache. Some laboratory abnormalities may occur, such as decreased lymphocytes, increased ALT and AST, and changes in sodium and calcium levels.
Retevmo signifies a significant advancement in the treatment of cancers driven by specific genetic alterations. Collaboration between patients and healthcare professionals is vital to determine the best treatment plan, manage side effects, and consider cost implications, ensuring that this revolutionary therapy is accessible to those in need.
Price in India: Retevmo
The cost of Retevmo varies in India based on factors like manufacturer, import regulations, and potential subsidies or discounts offered by healthcare providers. Consultation with healthcare providers or cancer treatment centers is crucial to obtain accurate and current pricing information. You can contact Indian Pharma for the best price of Retevmo.