Uses of Medicine: 

Pemetrexed 500 MG/100 MG injection is a folate analog metabolic inhibitor. It is supplied generically as well as as brand name medicine. Patients, Healthcare Professionals (HCPs), or Hospitals can buy Pemetrexed 100 mg/500 mg injection vials online from India through THE INDIAN PHARMA (a trusted Pemetrexed Supplier, Exporter, and Contract Manufacturer in India) for the management and treatment of:

  • Locally Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer: Pemetrexed 100 mg/500 mg injection, in combination with cisplatin, is used for the initial treatment of patients with locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC). It is also used as a maintenance therapy for patients whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. Additionally, This medicine is used as a single-agent treatment for patients with locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC) who have previously undergone chemotherapy.  
  • Malignant Pleural Mesothelioma (Cancers of the Lungs and Chest): Pemetrexed 100 mg/500 mg injection, in combination with cisplatin is used for the treatment of patients with malignant pleural mesothelioma whose disease is unresectable or who are otherwise not candidates for curative surgery. 

 

Limitations of Use:

Pemetrexed 100 mg/500 mg injection is not approved for the treatment of patients with squamous cell non-small cell lung cancer.

Pemetrexed 100 mg/500 mg injection is given alone or along with another anticancer medicine, such as cisplatin. Your healthcare provider (HCP) may also prescribe corticosteroids, folic acid, and vitamin B12. These help to reduce the side effects. Blood tests will be done before each infusion. These tests check if your kidney and liver functions are normal. They also check if you have enough blood cells to receive this medicine.

Before starting treatment with 100 mg/500 mg injection, inform your doctor about any past or current medical conditions. This includes kidney problems, heart disorders, or fluid buildup in the lungs. Tell your healthcare provider (HCP) if you recently had radiotherapy. Also, report if you have taken or plan to take any vaccinations before this treatment.

 

Dosage & Side Effects: 

Combination Use in Non-Small Cell Lung Cancer (NSCLC) and Mesothelioma:

The recommended dose of Pemetrexed injection is 500 mg/m2 administered as an intravenous (IV) infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Pemetrexed administration. Patients should receive appropriate hydration before and/or after receiving cisplatin.

Single-Agent Use in Non-Small Cell Lung Cancer:

The recommended dose of Pemetrexed is 500 mg/m2 administered as an intravenous (IV) infusion over 10 minutes on Day 1 of each 21-day cycle. Pemetrexed dose reductions or discontinuation may be required depending on toxicities from the preceding cycle of therapy.

The most common side effects of Pemetrexed as a monotherapy are fatigue, nausea, and anorexia. Additional common side effects when used along with cisplatin include vomiting, anemia, neutropenia, stomatitis/pharyngitis, leukopenia, thrombocytopenia, and constipation.