Cobimetinib

Fact of Medicine

  • Brand Name: Cotellic
  • Innovator Brand Name: Cotellic
  • API: Cobimetinib Fumarate
  • Packaging: 63 Tablets
  • Strength: 20mg
  • Manufacturer Name: Genentech

Cotellic – Cobimetinib 20 mg. is supplied for Tenders, Emergency imports, Orphan drug, Reference listed drugs, Comparator Drug, Name patient medicine, Bio-Similar and Innovator samples etc

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Description

Uses of medication: Cobimetinib is a kinase inhibitor used for the treatment of patients with unresectable/metastatic melanoma with a BRAF V600E or V600K mutation, together with the vemurafenib (Zelboraf).

Dosage: Take cobimetinib tablets exactly as your healthcare practitioner tells you. The recommended cobimetinib dose is 60 mg (three 20 mg tablets), which should be taken orally, either with or without food, once daily for the initial 21 days (3 week) of each 28-day cycle until the time of disease progression or unacceptable toxicity.

Treatment Reactions: The most commonly reported cobimetinib side effects may include:

  • Diarrhea
  • Photosensitivity reaction
  • Nausea
  • Pyrexia
  • Vomiting

Apart from this, the most common grade 3-4 laboratory abnormalities are as:

  • Increased GGT
  • Increased CP
  • Hypophosphatemia
  • Increased ALT
  • Lymphopenia
  • Increased AST
  • Hyponatremia
  • Increased alkaline phosphatase

Warnings and precautions

  • Avoid sunlight while on the treatment with cotellic 20 mg. This medication may be responsible for making your skin sensitive to the sunlight. You may burn a quite easily and get severe sunburns.
  • Monitor patients taking cobimetinib, when used together with vemurafenib, for signs/symptoms of non-cutaneous malignancies.
  • Serum creatinine should be measured prior to initiation of vemurafenib and periodically during treatment.
  • Cotellic can be responsible for causing fetal harm when given to a pregnant woman. Instruct females of reproductive potential to use effective contraception while on treatment and for 2 weeks following the final cotellic dose.
  • Advise women not to breastfeed during treatment with cobimetinib 20 mg tablet and for 2 weeks following the final dose.
  • Patients should be instructed to contact their healthcare practitioner in order to seek immediate medical attention for signs/symptoms of the unusual severe bleeding/hemorrhage.
  • Liver laboratory tests should be monitored prior to initiation of the vemurafenib cobimetinib and monthly while on treatment, or quite frequently as clinically indicated.
  • Dermatologic monitoring should be conducted for the 6 months following discontinuation of the cobimetinib fumarate when used together with the vemurafenib.

More Info.

Availability in India: The Indian Pharma (TIP) helps connect buyers with suppliers who can ship COTELLIC at the global level as per the need of buyer’s. The Indian Pharma provides guarantee of quality as well as delivery for the COTELLIC Tablets.

Buying Procedure: In order to buy COTELLIC, you can contact us at our Toll-free number 1800 889 1064 or on WhatsApp number +918130290915 or an Email to us at: info@theindianpharma.com along with your Identity Proof, Valid Prescription Letter and Medical Reports.

Conclusion: The cotellic 20 mg together with the vemurafenib is a valuable option for use in the BRAF (V600) mutation-positive unresectable or metastatic melanoma.

Commonly Asked Ques

What does Cotellic contain as an active substance?

The Cotellic specifically contains the active substance Cobimetinib.

From which class of drug Cobimetinib 20 mg belongs?

The cobimetinib 20 mg specifically belongs to the kinase inhibitors class of drug.

How does Cobimetinib act?

Falls under the kinase inhibitor class of drug, cobimetinib acts in order to block the action of an abnormal protein that signals cancer cells to multiply. This helps resist or block the spread of cancerous cells.

How much does cotellic cost?

The cotellic price in India may vary depending on the pharmacy you visit. The cotellic price for a supply of 63 tablets is around 527,256 INR.

Where can I get Cobimetinib at the best price?

In order to get the best cobimetinib price, always go with a such Pharmaceutical Wholesaler Company that holds the ISO and WHO-GDP certifications.

Can I get Cobimetinib (Cotellic) even if I am not based in India?

The Indian Pharma helps patients in accessing or importing Cotellic (Cobimetinib), not approved in their home country against the legitimate prescription and in conformity with the all local laws and regulations of their home country.

In how many countries COBIMETINIB is approved for marketing?

COBIMETINIB is available/approved in USA and Europe. We can help you to access it in India.

What is COBIMETINIB used for?

COBIMETINIB is indicated for the treatment of patients with un-resectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib.

How can I get COBIMETINIB in India?

COBIMETINIB is a prescription only drug and is not approved for marketing in India.

The Indian Pharma (IP) is a consulting pharmaceutical company which assists Patients in accessing medicines in India. The Indian Pharma facilitates such access only against valid prescriptions in conformity with all local laws and regulations.

Patients/ Clinicians / Researchers can contact IP at +91 9310090915 or write to at – info@theindianpharma.com

We facilitate by :-

  • Helping in documentation to import the medicine for personal use
  • Finding Genuine and reliable source in USA, Europe and Japan
  • Ensuring 100% transparency.

COBIMETINIB can be shipped to Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Jaipur, Lucknow, Cochin and Pune and other cities in India.

The Indian Pharma can facilitate the supply of COBIMETINIB (prescription medicine) to all locations in the world and in India after fulfilling the legal requirement.

The Indian Pharma does not manufacture, supply, re-sell or retail any drugs or medicines. All trademarks and other intellectual property in relation to drugs and medicines supplied to you by suppliers are owned by their respective manufacturers or licensees

Can I get COBIMETINIB even if I am not based in India?

Almost all countries across the world have provisions for granting access to drugs prior to marketing approval for personal use for patients who have exhausted all other treatment options available in their country

The Indian Pharma (IP) can help patients in accessing/importing COBIMETINIB, unapproved in their home country against a legitimate prescription and in conformity with all local laws and regulations of their home country.

Send your inquiry to find Cotellic (Cobimetinib 20 mg in UAE Iraq, Iran, Saudi Arabia, Jordan, Mexico, Argentina, Brazil, Chile, Colombia, Peru, Venezuela, Romania, Switzerland, Georgia, Turkey, Italy, UK, Ukraine, Azerbaijan, Latvia, Poland, Slovakia, Armenia, Kazakhstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan, Mongolia, Algeria, Mauritius, Uganda, Zimbabwe. Australia and New Zealand. China, Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, Vietnam, Hong Kong.

How is COBIMETINIB used?

COBIMETINIB should be administered under the guidance of specialist doctor having experience in managing cancer treatments.

Recommended dose: 60 mg orally once daily for the first 21 days of each 28-day cycle until disease progression or unacceptable toxicity. Can be taken with or without food.

If the patient develops certain serious side effects then doctor may interrupt or stop treatment, or reduce the dose. See the summary of product characteristics on company official website for more information

Are there any side-effects/ adverse reactions/precautions associated with treatment with COBIMETINIB?

It is recommended to seek your doctor’s medical advice about side effects

How do I contact The Indian Pharma?

You can use different channel to contact The Indian Pharma (IP)

Tele & Mobile: You can reach us on +91 9310090915 |Toll free -1800 889 1064 on any working days.

Email: We can also address your inquiries if sent directly to info@theindianpharma.com. We will respond within 24 hours after receiving your mail. Please mention detailed inquiry, your contact number with ISD code while sending your mail. We will respond within 1 working days after receiving your query form.

Documentation

What information do you need to help patient in assisting documentation for COBIMETINIB import for personal use?

We will require the following documents to help in documentation for Named-Patient import

  • Doctor’s Prescription – We would require prescription from Registered Medical Practitioner Stating Product name, dosage, duration of treatment and diagnosis
  • Patient’s Medical history – We would require all test reports and Medical reports of the patient for last 3 months.
  • Patient’s Identity card – We will require scan copy of Patient’s identity card and proof of residence to initiate documentation process. You can use copy of Passport, Driving License, Employee ID card or any Photo ID document as your Identity card.

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