Uses of medication: Dinutuximab is used in order to treat high-risk neuroblastoma in the babies, children and adolescents aged 12 months to 17 years old.

Dosage: The recommended dinutuximab dose should be administered to you by a healthcare practitioner. It should be administered as a drip into your veins (intravenous infusion) with certain other medications.

Treatment Reactions: The most commonly reported dinutuximab side effects include:

  • Pain
  • Pyrexia
  • Hypotension
  • Hyponatremia
  • Anemia
  • Vomiting
  • Diarrhea
  • Hypokalemia
  • Neutropenia
  • Urticaria
  • Hypoalbuminemia
  • Hypocalcemia
  • Thrombocytopenia
  • Lymphopenia
  • Capillary leak syndrome
  • Infusion reactions
  • Increased alanine aminotransferase
  • Increased aspartate aminotransferase

Warnings and Precautions:

  • Use of unituxin injection is contraindicated in those patients who are with a history of anaphylaxis to dinutuximab.
  • Patients should be monitored closely for the signs/symptoms of infusion reactions while on and for a minimum 4-hours after the completion of each infusion of unituxin injection.
  • Use of this medication should be promptly interrupted or permanently discontinued and institute supportive management in case of severe or prolonged infusion reactions.
  • Prior to each Unituxin Dinutuximab Injection infusion, administer needed intravenous hydration, and patients should be closely monitored for blood pressure while on treatment.
  • Patients should be monitored for the peripheral blood counts closely and serum electrolytes daily while on the dinutuximab injection therapy.
  • Pregnant women are advised that use of this medication during pregnancy may cause fetal harm, so use should be avoided.
  • Breastfeed needs to be avoided during treatment with dinutuximab injection. This is because this drug may pass into breast-milk.