Topotec — Topotecan
Topotecan occupies a specific, valuable position as a second-line chemotherapy option — it's used when cancer has recurred after initial treatment or when surgery and radiotherapy haven't worked, which means demand for this product often comes from hospitals managing more advanced or treatment-resistant cases rather than newly diagnosed patients.
- Approved indications: Recurrent ovarian cancer and small-cell lung cancer after prior chemotherapy; advanced cervical cancer (combined with cisplatin) when surgery or radiotherapy hasn't worked
- Mechanism: Interferes with DNA topoisomerase I function, preventing cancer cells from dividing and growing, leading to tumor regression
- Combination therapy: Used alone for ovarian and lung cancer recurrence; combined with cisplatin specifically for advanced cervical cancer
- Dietary interaction note: Patients are advised to avoid grapefruit and grapefruit juice, which can increase drug levels in the body and elevate side-effect risk — a detail worth including in patient counseling materials provided with the product
Key Product Facts
2.5mg (2.5mL vial)
Strength
Single-dose vial
Pack Size
Topotecan
Active Ingredient
Oncology
Category
On Request
Availability
Topotecan occupies a specific, valuable position as a second-line chemotherapy option — it's used when cancer has recurred after initial treatment or when surgery and radiotherapy haven't worked, which means demand for this product often comes from hospitals managing more advanced or treatment-resistant cases rather than newly diagnosed patients.
- Approved indications: Recurrent ovarian cancer and small-cell lung cancer after prior chemotherapy; advanced cervical cancer (combined with cisplatin) when surgery or radiotherapy hasn't worked
- Mechanism: Interferes with DNA topoisomerase I function, preventing cancer cells from dividing and growing, leading to tumor regression
- Combination therapy: Used alone for ovarian and lung cancer recurrence; combined with cisplatin specifically for advanced cervical cancer
- Dietary interaction note: Patients are advised to avoid grapefruit and grapefruit juice, which can increase drug levels in the body and elevate side-effect risk — a detail worth including in patient counseling materials provided with the product
- Bone marrow suppression: A significant risk requiring regular blood count monitoring — increased risk of infection, anemia, and bleeding
- Pediatric use: Not recommended for pediatric patients
- Hepatic risk: Can elevate liver enzymes, requiring regular liver function monitoring
- Pregnancy: Unsafe, can cause fetal harm — contraception required during treatment and for at least 2 weeks after the last dose
- Neurological symptoms: Numbness, tingling, or confusion should be reported promptly
| Document |
Included |
| Certificate of Analysis (COA) |
? Standard |
| Certificate of Origin (COO) |
? Standard |
| MSDS |
? Standard |
Stock status: In stock for export | Quote turnaround: 24 hours
- Logistics: GDP-compliant cold-chain export (2–8°C)
- Coverage: Global export markets
- Tracking: Full shipment tracking included
What is Topotecan used for?
Treats recurrent ovarian cancer, small-cell lung cancer, and advanced cervical cancer when other treatments haven't worked.
Get Topotecan price from a GMP-compliant Indian supplier — how?
Send strength and destination for a verified quote.
Can it affect blood counts?
Yes, bone marrow suppression is a significant risk requiring regular monitoring throughout treatment.
Should patients avoid certain foods?
Yes, grapefruit and grapefruit juice should be avoided as they can increase drug levels and side-effect risk.
Who supplies Topotecan from India?
WHO-GMP certified manufacturer with full export documentation.
